Dstyk dual serine/threonine and tyrosine protein kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dstykprovided by RGD
Official Full Name: dual serine/threonine and tyrosine protein kinaseprovided by RGD
Primary source: RGD:735051
See related: EnsemblRapid:ENSRNOG00000021298 AllianceGenome:RGD:735051
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ripk5; DustyPK
Summary: Predicted to enable ATP binding activity and protein kinase activity. Predicted to be involved in several processes, including cellular response to fibroblast growth factor stimulus; positive regulation of kinase activity; and positive regulation of signal transduction. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in CAKUT1 and hereditary spastic paraplegia 23. Orthologous to human DSTYK (dual serine/threonine and tyrosine protein kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 120.9), Kidney (RPKM 73.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (46409412..46457426)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (43857266..43905280)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (49195325..49243327)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D13Got25 (e-PCR)
- UniSTS:111964

STS-M62021 (e-PCR)
- UniSTS:26245

BF390479 (e-PCR)
- UniSTS:249481

RH137708 (e-PCR)
- UniSTS:219795

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to fibroblast growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to fibroblast growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to fibroblast growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fibroblast growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dual serine/threonine and tyrosine protein kinase

Names: dusty PK; dusty protein kinase; receptor interacting protein kinase 5; receptor-interacting serine/threonine-protein kinase 5

NP_955750.1

EC 2.7.12.1

XP_006249836.1

EC 2.7.12.1

XP_063128356.1

EC 2.7.12.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199463.2 → NP_955750.1 dual serine/threonine and tyrosine protein kinase

See identical proteins and their annotated locations for NP_955750.1

Status: PROVISIONAL

Source sequence(s)

AY429675

UniProtKB/Swiss-Prot

Q6XUX2

UniProtKB/TrEMBL

A0A8L2UHS8

Related

ENSRNOP00000004810.5, ENSRNOT00000004810.7

Conserved Domains (2) summary

smart00220
Location:651 → 895

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13975
Location:649 → 910

PKc_Dusty; Catalytic domain of the Dual-specificity Protein Kinase, Dusty

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

46409412..46457426

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249774.4 → XP_006249836.1 dual serine/threonine and tyrosine protein kinase isoform X1

See identical proteins and their annotated locations for XP_006249836.1

UniProtKB/TrEMBL

A0A8L2UHS8, A6IC51

Conserved Domains (1) summary

cd13975
Location:551 → 812

PKc_Dusty; Catalytic domain of the Dual-specificity Protein Kinase, Dusty
XM_063272286.1 → XP_063128356.1 dual serine/threonine and tyrosine protein kinase isoform X2