Rnf2 ring finger protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnf2provided by RGD
Official Full Name: ring finger protein 2provided by RGD
Primary source: RGD:1305491
See related: EnsemblRapid:ENSRNOG00000002454 AllianceGenome:RGD:1305491
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including RING-like zinc finger domain binding activity; histone H2AK119 ubiquitin ligase activity; and zinc ion binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in response to retinoic acid and spinal cord development. Predicted to be located in euchromatin; nuclear body; and sex chromatin. Predicted to be part of MLL1 complex and PRC1 complex. Predicted to be active in cytoplasm and nucleus. Biomarker of spina bifida. Human ortholog(s) of this gene implicated in Luo-Schoch-Yamamoto syndrome. Orthologous to human RNF2 (ring finger protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 232.3), Muscle (RPKM 136.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (66103943..66136038, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (63553964..63584047, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (68829714..68859920, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143600 (e-PCR)
- UniSTS:232846

AW533161 (e-PCR)
- UniSTS:260502

RH129133 (e-PCR)
- UniSTS:212441

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RING-like zinc finger domain binding	IEA Inferred from Electronic Annotation more info
enables RING-like zinc finger domain binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone H2AK119 ubiquitin ligase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AK119 ubiquitin ligase activity	ISO Inferred from Sequence Orthology more info
enables histone H2AK119 ubiquitin ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
contributes_to ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in anterior/posterior axis specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior axis specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in epigenetic regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in epigenetic regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in epigenetic regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in gastrulation with mouth forming second	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gastrulation with mouth forming second	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_negative_effect gene expression	ISO Inferred from Sequence Orthology more info
involved_in germ cell development	IEA Inferred from Electronic Annotation more info
involved_in germ cell development	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in spinal cord development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of MLL1 complex	IEA Inferred from Electronic Annotation more info
part_of MLL1 complex	ISO Inferred from Sequence Orthology more info
part_of MLL1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of PRC1 complex	IEA Inferred from Electronic Annotation more info
part_of PRC1 complex	ISO Inferred from Sequence Orthology more info
part_of PRC1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of PcG protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
part_of PcG protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in euchromatin	IEA Inferred from Electronic Annotation more info
located_in euchromatin	ISO Inferred from Sequence Orthology more info
located_in heterochromatin	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in sex chromatin	IEA Inferred from Electronic Annotation more info
located_in sex chromatin	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RING2

Names: RING finger protein 1B; RING-type E3 ubiquitin transferase RING2; RING1b

NP_001388309.1

EC 2.3.2.27

XP_063128385.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401380.1 → NP_001388309.1 E3 ubiquitin-protein ligase RING2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A0G2JTP7, A6ICS7

Related

ENSRNOP00000097279.1, ENSRNOT00000100223.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

66103943..66136038 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272315.1 → XP_063128385.1 E3 ubiquitin-protein ligase RING2 isoform X1

UniProtKB/TrEMBL

A0A0G2JTP7, A6ICS7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001025667.1: Suppressed sequence

Description

NM_001025667.1: This RefSeq was removed because currently there is insufficient support for the transcript.