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Trmt1l tRNA methyltransferase 1-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 304851, updated on 4-Jan-2025

Summary

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Official Symbol
Trmt1lprovided by RGD
Official Full Name
tRNA methyltransferase 1-likeprovided by RGD
Primary source
RGD:1307890
See related
EnsemblRapid:ENSRNOG00000002580 AllianceGenome:RGD:1307890
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Trm1l; RGD1307890
Summary
Predicted to enable metal ion binding activity; tRNA (guanine) methyltransferase activity; and tRNA binding activity. Predicted to be involved in tRNA N2-guanine methylation. Predicted to act upstream of or within adult locomotory behavior. Predicted to be active in nucleus. Orthologous to human TRMT1L (tRNA methyltransferase 1 like). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 131.3), Thymus (RPKM 119.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trmt1l in Genome Data Viewer
Location:
13q21
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (66060186..66093247)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (63510097..63543268)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (68785889..68819018)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene influenza virus NS1A binding protein Neighboring gene SWT1 RNA endoribonuclease homolog Neighboring gene ring finger protein 2 Neighboring gene small ribosomal subunit protein uS3-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour. Vauti F, et al. Gene, 2007 Mar 15. PMID 17198746
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124643

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (guanine) methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adult behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA N2-guanine methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TRMT1-like protein
Names
TRM1 tRNA methyltransferase 1-like
TRM1-like protein
tRNA methyltransferase 1 homolog-like
NP_001032269.1
XP_006250054.1
XP_006250055.1
XP_017454296.1
XP_038946661.1
XP_038946662.1
XP_063128387.1
XP_063128388.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037192.1 → NP_001032269.1  TRMT1-like protein

    See identical proteins and their annotated locations for NP_001032269.1

    Status: PROVISIONAL

    Source sequence(s)
    BC100650
    UniProtKB/Swiss-Prot
    Q496Z9
    UniProtKB/TrEMBL
    A0A8I5ZWS2
    Related
    ENSRNOP00000082306.1, ENSRNOT00000094165.2
    Conserved Domains (2) summary
    cl17173
    Location:244 → 683
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cl22851
    Location:153 → 198
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    66060186..66093247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598807.3 → XP_017454296.1  TRMT1-like protein isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:95 → 534
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_006249992.5 → XP_006250054.1  TRMT1-like protein isoform X1

    See identical proteins and their annotated locations for XP_006250054.1

    UniProtKB/TrEMBL
    A0A8I5ZWS2, A6ICS6
    Related
    ENSRNOP00000104439.1, ENSRNOT00000134317.1
    Conserved Domains (2) summary
    cl17173
    Location:246 → 685
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cl22851
    Location:155 → 200
    PHD_SF; PHD finger superfamily

  3. XM_006249993.5 → XP_006250055.1  TRMT1-like protein isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZWS2
    Related
    ENSRNOP00000003517.8, ENSRNOT00000003517.9
    Conserved Domains (2) summary
    cl17173
    Location:246 → 664
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cl22851
    Location:155 → 200
    PHD_SF; PHD finger superfamily

  4. XM_063272317.1 → XP_063128387.1  TRMT1-like protein isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZWS2, A0A8L2Q0A9

  5. XM_063272318.1 → XP_063128388.1  TRMT1-like protein isoform X4

  6. XM_039090733.1 → XP_038946661.1  TRMT1-like protein isoform X5

    Conserved Domains (1) summary
    cl17173
    Location:16 → 419
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  7. XM_039090734.1 → XP_038946662.1  TRMT1-like protein isoform X6

    Conserved Domains (1) summary
    cl17173
    Location:10 → 402
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. XR_005492245.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q496Z9.1 GenPept UniProtKB/Swiss-Prot:Q496Z9

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