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Uck2 uridine-cytidine kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304944, updated on 27-Nov-2024

Summary

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Official Symbol
Uck2provided by RGD
Official Full Name
uridine-cytidine kinase 2provided by RGD
Primary source
RGD:620742
See related
EnsemblRapid:ENSRNOG00000003917 AllianceGenome:RGD:620742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Umpk
Summary
Predicted to enable cytidine kinase activity; identical protein binding activity; and uridine kinase activity. Involved in cellular response to oxygen levels; feeding behavior; and response to axon injury. Predicted to be active in cytoplasm. Orthologous to human UCK2 (uridine-cytidine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 118.5), Heart (RPKM 80.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Uck2 in Genome Data Viewer
Location:
13q24
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (81913732..81971036, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (79380807..79438121, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (85376716..85443976, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29, pseudogene 20 Neighboring gene small nucleolar RNA U13 Neighboring gene transmembrane and coiled-coil domains 1 Neighboring gene aldehyde dehydrogenase 9 family, member A1 Neighboring gene NOP10 ribonucleoprotein like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sensitivity of human cancer cells to the new anticancer ribo-nucleoside TAS-106 is correlated with expression of uridine-cytidine kinase 2. Shimamoto Y, et al. Jpn J Cancer Res, 2002 Jul. PMID 12149149, Free PMC Article
  2. Postnatal ontogeny of uridine kinase in the cerebellum, hypothalamus, and cerebral cortex of the rat. Litteria M, et al. Neurochem Res, 1985 Jan. PMID 2984595
  3. Adverse effects of hyperbaric oxygen on [3H]uridine incorporation and uridine kinase activity in B104 rat neuroblastoma cells. Gendimenico GJ, et al. Mol Cell Biochem, 1990 Jun 1. PMID 2164139
  4. Effect of diabetes and fasting on the uridine triphosphate content and uridine kinase activity of rat cardiac and skeletal muscle. Gertz BJ, et al. Metabolism, 1979 Apr. PMID 221781
  5. Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase. Suzuki NN, et al. Structure, 2004 May. PMID 15130468

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cytidine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cytidine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cytidine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables uridine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables uridine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables uridine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in CMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in CTP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in CTP salvage ISO
Inferred from Sequence Orthology
more info
  
involved_in CTP salvage ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in UMP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in UMP salvage ISO
Inferred from Sequence Orthology
more info
  
involved_in UMP salvage ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to oxygen levels IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in feeding behavior IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in protein deubiquitination TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to axon injury IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uridine-cytidine kinase 2
Names
UCK 2
cytidine monophosphokinase 2
uridine monophosphate kinase
uridine monophosphokinase 2
NP_001402675.1
XP_038946718.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415746.1 → NP_001402675.1  uridine-cytidine kinase 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    B2RZ83, Q9QYG8
    Related
    ENSRNOP00000068308.2, ENSRNOT00000076125.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    81913732..81971036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090790.2 → XP_038946718.1  uridine-cytidine kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AI33
    Related
    ENSRNOP00000095493.2, ENSRNOT00000098075.2
    Conserved Domains (1) summary
    cd02023
    Location:38 → 234
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001102408.2: Suppressed sequence

    Description
    NM_001102408.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYG8.2 GenPept UniProtKB/Swiss-Prot:Q9QYG8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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