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Tagln2 transgelin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304983, updated on 27-Nov-2024

Summary

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Official Symbol
Tagln2provided by RGD
Official Full Name
transgelin 2provided by RGD
Primary source
RGD:1310840
See related
EnsemblRapid:ENSRNOG00000008301 AllianceGenome:RGD:1310840
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and epithelial cell differentiation. Predicted to be active in actin cytoskeleton. Orthologous to human TAGLN2 (transgelin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 1592.2), Heart (RPKM 642.7) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tagln2 in Genome Data Viewer
Location:
13q24
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (87499350..87506328)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (84966980..84973973)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (90807196..90814119, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene SLAM family member 9 Neighboring gene immunoglobulin superfamily, member 9 Neighboring gene uncharacterized LOC134481593 Neighboring gene cilia and flagella associated protein 45 Neighboring gene uncharacterized LOC120096318

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2. Buhrke T, et al. Dev Growth Differ, 2011 Apr. PMID 21492153
  2. Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. Kesimer M, et al. FASEB J, 2009 Jun. PMID 19190083, Free PMC Article
  3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
  4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
  5. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transgelin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013127.1 → NP_001013145.1  transgelin-2

    See identical proteins and their annotated locations for NP_001013145.1

    Status: PROVISIONAL

    Source sequence(s)
    BC084703
    UniProtKB/Swiss-Prot
    Q5XFX0
    UniProtKB/TrEMBL
    A0A8I5ZRB4, A6JG61
    Conserved Domains (2) summary
    pfam00402
    Location:174 → 198
    Calponin; Calponin family repeat
    cd21280
    Location:18 → 154
    CH_TAGLN2; calponin homology (CH) domain found in transgelin-2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    87499350..87506328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090801.2 → XP_038946729.1  transgelin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q5XFX0
    UniProtKB/TrEMBL
    A0A8I5ZRB4, A6JG61
    Related
    ENSRNOP00000011208.4, ENSRNOT00000011208.9
    Conserved Domains (2) summary
    pfam00402
    Location:174 → 198
    Calponin; Calponin family repeat
    cd21280
    Location:18 → 154
    CH_TAGLN2; calponin homology (CH) domain found in transgelin-2

  2. XM_006250295.4 → XP_006250357.1  transgelin-2 isoform X1

    See identical proteins and their annotated locations for XP_006250357.1

    UniProtKB/Swiss-Prot
    Q5XFX0
    UniProtKB/TrEMBL
    A0A8I5ZRB4, A6JG61
    Conserved Domains (2) summary
    pfam00402
    Location:174 → 198
    Calponin; Calponin family repeat
    cd21280
    Location:18 → 154
    CH_TAGLN2; calponin homology (CH) domain found in transgelin-2

  3. XM_063272375.1 → XP_063128445.1  transgelin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q5XFX0
    UniProtKB/TrEMBL
    A6JG61
    Related
    ENSRNOP00000081124.1, ENSRNOT00000102023.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XFX0.1 GenPept UniProtKB/Swiss-Prot:Q5XFX0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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