Cd34 CD34 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd34provided by RGD
Official Full Name: CD34 moleculeprovided by RGD
Primary source: RGD:1306863
See related: EnsemblRapid:ENSRNOG00000045558 AllianceGenome:RGD:1306863
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; carbohydrate binding activity; and sulfate binding activity. Involved in glomerular filtration and mesangial cell-matrix adhesion. Located in apical plasma membrane; basal plasma membrane; and lysosome. Part of glomerular endothelium fenestra. Biomarker of diabetic retinopathy. Orthologous to human CD34 (CD34 molecule). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Heart (RPKM 753.0), Lung (RPKM 440.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q27

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (109008786..109029317)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (106480313..106500844)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (113691842..113711259)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ultrastructural aberrations, histological disruption and upregulation of the VEGF, CD34 and ASMA immunoexpression in the myocardium of anemic albino rats.
Title: Ultrastructural aberrations, histological disruption and upregulation of the VEGF, CD34 and ASMA immunoexpression in the myocardium of anemic albino rats.
This study reports an increased number and proliferation of CD34+ cells in SOD1G93A rat spinal cord during paralysis progression.
Title: CD34 Identifies a Subset of Proliferating Microglial Cells Associated with Degenerating Motor Neurons in ALS.
Estrogen has dual effects on CD34(+) vascular wall-resident CD34(+) stem/progenitor cells altering cell proliferation and differentiation.
Title: Effects of estrogen on growth and smooth muscle differentiation of vascular wall-resident CD34(+) stem/progenitor cells.
Data show that the synovial angiogenesis is associated with the over-expressions of hypoxia inducible factor 1alpha (HIF-1alpha), vascular endothelial growth factor (VEGF) and CD34 antigen in adjuvant arthritis.
Title: [Up-regulated expressions of HIF-1α, VEGF and CD34 promote synovial angiogenesis in rats with adjuvant arthritis].
Shock wave therapy leads to mobilization of endogenous CD31/CD34-positive endothelial cells.
Title: Shock wave treatment induces angiogenesis and mobilizes endogenous CD31/CD34-positive endothelial cells in a hindlimb ischemia model: implications for angiogenesis and vasculogenesis.
positive impact of Sdf-1 on muscle regeneration is related to the mobilisation of endogenous cells, that is satellite cells and myoblasts, as well as non-muscle stem cells, expressing Cxcr4 and CD34.
Title: Sdf-1 (CXCL12) improves skeletal muscle regeneration via the mobilisation of Cxcr4 and CD34 expressing cells.
Igf1r+/CD34+ immature ICC are putative adult progenitor cells, identified ultrastructurally as fibroblast-like ICC in Ws/Ws rat colon
Title: Igf1r+/CD34+ immature ICC are putative adult progenitor cells, identified ultrastructurally as fibroblast-like ICC in Ws/Ws rat colon.
After ischemia/reperfusion injury in kidney, the expression rates of CD34 and Brdu antigen rise obviously in cortex renis.
Title: [Influence and distribution of CD133 and CD34 antigen expression in proximal tubule epithelial cells during ischemia/reperfusion injury in rats].
With the increase of age, the expression of TGF-beta1 is significantly up-regulated, while those of Desmin and CD34 significantly down-regulated in corpus cavernosum tissues.
Title: [Expressions of transforming growth factor-beta1, desmin and CD34 in the penile corpus cavernosum of rats].
first complete sequence of a rat CD34 variant shows for the first time that the encoded truncated variant is endogenously expressed on endothelia in vivo
Title: Immunotargeting and cloning of two CD34 variants exhibiting restricted expression in adult rat endothelia in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	ISS Inferred from Sequence or Structural Similarity more info
enables sulfate binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell motility	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelium development	ISO Inferred from Sequence Orthology more info
involved_in extracellular exosome assembly	ISO Inferred from Sequence Orthology more info
involved_in extracellular exosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in glomerular endothelium development	ISO Inferred from Sequence Orthology more info
involved_in glomerular filtration	IEP Inferred from Expression Pattern more info	PubMed
involved_in glomerular filtration	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic stem cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in hemopoiesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in mesangial cell-matrix adhesion	IEP Inferred from Expression Pattern more info	PubMed
involved_in metanephric glomerular mesangial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-2 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in paracrine signaling	ISO Inferred from Sequence Orthology more info
involved_in paracrine signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granulocyte colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granulocyte colony-stimulating factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of odontogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in tissue homeostasis	ISO Inferred from Sequence Orthology more info
involved_in tissue homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in transdifferentiation	ISO Inferred from Sequence Orthology more info
involved_in vascular wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
part_of glomerular endothelium fenestra	IDA Inferred from Direct Assay more info	PubMed
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hematopoietic progenitor cell antigen CD34

Names: CD34 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.