oprd1a opioid receptor, delta 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: oprd1aprovided by ZNC
Official Full Name: opioid receptor, delta 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-199
See related: Ensembl:ENSDARG00000041660 AllianceGenome:ZFIN:ZDB-GENE-990415-199
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ZFOR1; oprd1
Summary: Enables G protein-coupled enkephalin receptor activity. Acts upstream of or within G protein-coupled opioid receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including central nervous system; neural tube; notochord; prechordal plate; and trunk. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; drug dependence (multiple); opioid abuse; and withdrawal disorder. Orthologous to human OPRD1 (opioid receptor delta 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (14920968..14951756)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (15016606..15047394)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled enkephalin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled enkephalin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled opioid receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled opioid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: opioid receptor, delta 1a

Names: ZfDOR1; opioid receptor homolog; opioid receptor, delta 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131258.4 → NP_571333.2 opioid receptor, delta 1a

Status: VALIDATED

Source sequence(s)

BC162477, CR394532

UniProtKB/TrEMBL

A0A8M1PAZ1, A3QJX7

Related

ENSDARP00000122239.1, ENSDART00000144052.2

Conserved Domains (2) summary

pfam00001
Location:70 → 323

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:62 → 269

7tm_4; Olfactory receptor