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Nudt9 nudix hydrolase 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305149, updated on 27-Nov-2024

Summary

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Official Symbol
Nudt9provided by RGD
Official Full Name
nudix hydrolase 9provided by RGD
Primary source
RGD:1359522
See related
EnsemblRapid:ENSRNOG00000002186 AllianceGenome:RGD:1359522
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ADP-ribose diphosphatase activity. Predicted to act upstream of or within ADP catabolic process. Predicted to be located in cell junction; nuclear body; and nuclear membrane. Predicted to be active in mitochondrion. Orthologous to human NUDT9 (nudix hydrolase 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 144.3), Brain (RPKM 103.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nudt9 in Genome Data Viewer
Location:
14p22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (5980042..5997998, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (5675376..5693332, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (7036809..7054739, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene SPARC like 1 Neighboring gene secretory calcium-binding phosphoprotein proline-glutamine rich 1 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 11 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 13 Neighboring gene uncharacterized LOC120096561 Neighboring gene kelch-like family member 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The crystal structure and mutational analysis of human NUDT9. Shen BW, et al. J Mol Biol, 2003 Sep 12. PMID 12948489
  2. NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase. Perraud AL, et al. J Biol Chem, 2003 Jan 17. PMID 12427752
  3. Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose). Lin S, et al. Biochim Biophys Acta, 2002 Jan 31. PMID 11825615
  4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC94618

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ADP-ribose diphosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ADP catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ADP-ribose pyrophosphatase, mitochondrial
Names
ADP-ribose diphosphatase
ADP-ribose phosphohydrolase
ADPR-PPase
adenosine diphosphoribose pyrophosphatase
nucleoside diphosphate-linked moiety X motif 9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
nudix motif 9
nudix-type motif 9
NP_001006992.1
XP_006250692.1
XP_006250693.1
XP_017454652.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006991.1 → NP_001006992.1  ADP-ribose pyrophosphatase, mitochondrial

    See identical proteins and their annotated locations for NP_001006992.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083722
    UniProtKB/Swiss-Prot
    Q5XIG0
    Related
    ENSRNOP00000002973.3, ENSRNOT00000002973.6
    Conserved Domains (1) summary
    cd03670
    Location:149 → 335
    ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    5980042..5997998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250630.4 → XP_006250692.1  ADP-ribose pyrophosphatase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006250692.1

    UniProtKB/TrEMBL
    A6K5T5
    Conserved Domains (1) summary
    cd03670
    Location:99 → 285
    ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...

  2. XM_006250631.5 → XP_006250693.1  ADP-ribose pyrophosphatase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006250693.1

    UniProtKB/TrEMBL
    A6K5T5
    Related
    ENSRNOP00000105881.1, ENSRNOT00000155501.1
    Conserved Domains (1) summary
    cd03670
    Location:99 → 285
    ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...

  3. XM_017599163.3 → XP_017454652.1  ADP-ribose pyrophosphatase, mitochondrial isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIG0.1 GenPept UniProtKB/Swiss-Prot:Q5XIG0

Gene LinkOut

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