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Rasl11b RAS-like family 11 member B [ Rattus norvegicus (Norway rat) ]

Gene ID: 305302, updated on 27-Nov-2024

Summary

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Symbol
Rasl11bprovided by RGD
Full Name
RAS-like family 11 member Bprovided by RGD
Primary source
RGD:1303099
See related
EnsemblRapid:ENSRNOG00000002097 AllianceGenome:RGD:1303099
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transforming growth factor beta receptor binding activity. Predicted to act upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway. Orthologous to human RASL11B (RAS like family 11 member B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 121.5), Heart (RPKM 81.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rasl11b in Genome Data Viewer
Location:
14p11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (34369029..34373250, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (34014924..34019146, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (36550353..36554574, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ligand of numb-protein X 1 Neighboring gene factor interacting with PAPOLA and CPSF1 Neighboring gene sec1 family domain containing 2 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134481840 Neighboring gene uncharacterized LOC102554412

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. Finlin BS, et al. J Biol Chem, 2001 Nov 9. PMID 11533059
  2. RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta. Piek E, et al. Biochem J, 2004 Oct 1. PMID 15239668, Free PMC Article
  3. RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors. Louro R, et al. Biochem Biophys Res Commun, 2004 Apr 9. PMID 15033445
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables transforming growth factor beta receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras-like protein family member 11B
NP_001002830.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002830.2 → NP_001002830.1  ras-like protein family member 11B

    See identical proteins and their annotated locations for NP_001002830.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083755
    UniProtKB/Swiss-Prot
    Q6IMA7
    UniProtKB/TrEMBL
    A0A8I6GM65, A6JD21
    Related
    ENSRNOP00000002869.3, ENSRNOT00000002869.7
    Conserved Domains (1) summary
    cd04146
    Location:34 → 201
    RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    34369029..34373250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IMA7.1 GenPept UniProtKB/Swiss-Prot:Q6IMA7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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