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Urgcp upregulator of cell proliferation [ Rattus norvegicus (Norway rat) ]

Gene ID: 305493, updated on 27-Nov-2024

Summary

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Official Symbol
Urgcpprovided by RGD
Official Full Name
upregulator of cell proliferationprovided by RGD
Primary source
RGD:1564681
See related
EnsemblRapid:ENSRNOG00000012184 AllianceGenome:RGD:1564681
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Urg4; RGD1564681
Summary
Predicted to enable GTP binding activity. Predicted to be located in cytosol. Orthologous to human URGCP (upregulator of cell proliferation). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 170.8), Heart (RPKM 164.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Urgcp in Genome Data Viewer
Location:
14q21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84808616..84852785, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (80594637..80638972, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (85957726..86002227, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 48 Neighboring gene ribosomal protein L18, pseudogene 8 Neighboring gene mitochondrial ribosomal protein S24 Neighboring gene ubiquitin-conjugating enzyme E2D 4 like, pseudogene 2 Neighboring gene drebrin-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
up-regulator of cell proliferation
Names
up-regulated gene 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077660.2 → NP_001071128.1  up-regulator of cell proliferation

    See identical proteins and their annotated locations for NP_001071128.1

    Status: VALIDATED

    Source sequence(s)
    BI285944, DN931704, DN934843, EX490902, FM041979, FM044330, FM046879, FM056971
    UniProtKB/TrEMBL
    A0A096MJ37, A0A8I6AE57, A6IKN3
    Related
    ENSRNOP00000067978.2, ENSRNOT00000076874.4
    Conserved Domains (1) summary
    cl21455
    Location:693 → 793
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    84808616..84852785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273225.1 → XP_063129295.1  up-regulator of cell proliferation isoform X2

    UniProtKB/TrEMBL
    A6IKN4

  2. XM_039092051.2 → XP_038947979.1  up-regulator of cell proliferation isoform X3

    UniProtKB/TrEMBL
    F1M5F4
    Related
    ENSRNOP00000101502.1, ENSRNOT00000165193.1
    Conserved Domains (2) summary
    cl27170
    Location:333 → 466
    DUF460; Protein of unknown function (DUF460)
    cl38936
    Location:618 → 718
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_006251312.5 → XP_006251374.1  up-regulator of cell proliferation isoform X2

    See identical proteins and their annotated locations for XP_006251374.1

    UniProtKB/TrEMBL
    A6IKN4, F1M5F4
    Conserved Domains (1) summary
    cl21455
    Location:650 → 750
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. XM_039092050.2 → XP_038947978.1  up-regulator of cell proliferation isoform X1

    UniProtKB/TrEMBL
    A0A096MJH4, F1M5F4
    Conserved Domains (2) summary
    cl27170
    Location:391 → 524
    DUF460; Protein of unknown function (DUF460)
    cl38936
    Location:676 → 776
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. XM_006251315.5 → XP_006251377.1  up-regulator of cell proliferation isoform X2

    See identical proteins and their annotated locations for XP_006251377.1

    UniProtKB/TrEMBL
    A6IKN4, F1M5F4
    Related
    ENSRNOP00000016468.7, ENSRNOT00000016468.7
    Conserved Domains (1) summary
    cl21455
    Location:650 → 750
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  6. XM_063273223.1 → XP_063129293.1  up-regulator of cell proliferation isoform X2

    UniProtKB/TrEMBL
    A6IKN4

  7. XM_039092052.2 → XP_038947980.1  up-regulator of cell proliferation isoform X3

    UniProtKB/TrEMBL
    F1M5F4
    Related
    ENSRNOP00000068129.3, ENSRNOT00000076740.4
    Conserved Domains (2) summary
    cl27170
    Location:333 → 466
    DUF460; Protein of unknown function (DUF460)
    cl38936
    Location:618 → 718
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version

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