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Fezf2 Fez family zinc finger 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305719, updated on 27-Nov-2024

Summary

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Official Symbol
Fezf2provided by RGD
Official Full Name
Fez family zinc finger 2provided by RGD
Primary source
RGD:1311068
See related
EnsemblRapid:ENSRNOG00000009206 AllianceGenome:RGD:1311068
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zfp312
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in several processes, including cell dedifferentiation; positive regulation of DNA-templated transcription; and regulation of neurogenesis. Predicted to act upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; nervous system development; and regulation of neuron differentiation. Predicted to be located in nucleus. Orthologous to human FEZF2 (FEZ family zinc finger 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 21.8) and Thymus (RPKM 7.6) See more
Orthologs
human mouse all
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Genomic context

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See Fezf2 in Genome Data Viewer
Location:
15p15
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (15199045..15207982)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (12768614..12777554)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (12825333..12831496)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene calcium dependent secretion activator Neighboring gene Histone deacetylase 1, pseudogene 3 Neighboring gene ribosomal protein S27, pseudogene 4 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene centrosomal protein 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Zfp312 is required for subcortical axonal projections and dendritic morphology of deep-layer pyramidal neurons of the cerebral cortex. Chen JG, et al. Proc Natl Acad Sci U S A, 2005 Dec 6. PMID 16314561, Free PMC Article
  2. Zinc finger gene fez-like functions in the formation of subplate neurons and thalamocortical axons. Hirata T, et al. Dev Dyn, 2004 Jul. PMID 15188439
  3. dFezf/Earmuff maintains the restricted developmental potential of intermediate neural progenitors in Drosophila. Weng M, et al. Dev Cell, 2010 Jan 19. PMID 20152183, Free PMC Article
  4. A network of genetic repression and derepression specifies projection fates in the developing neocortex. Srinivasan K, et al. Proc Natl Acad Sci U S A, 2012 Nov 20. PMID 23144223, Free PMC Article
  5. Excitatory projection neuron subtypes control the distribution of local inhibitory interneurons in the cerebral cortex. Lodato S, et al. Neuron, 2011 Feb 24. PMID 21338885, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of GABAergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within axonal fasciculation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell dedifferentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebral cortex GABAergic interneuron migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebral cortex neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within commitment of neuronal cell to specific neuron type in forebrain ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dendrite development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dentate gyrus development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within forebrain anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within forebrain development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron fate determination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within telencephalon development ISO
Inferred from Sequence Orthology
more info
  
involved_in telencephalon development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fez family zinc finger protein 2
Names
zinc finger protein 312

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107251.1 → NP_001100721.1  fez family zinc finger protein 2

    See identical proteins and their annotated locations for NP_001100721.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474010
    UniProtKB/TrEMBL
    A6K089, B4F7C0, F7ERI8
    Related
    ENSRNOP00000012452.4, ENSRNOT00000012452.7
    Conserved Domains (4) summary
    COG5048
    Location:284 → 390
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:380 → 436
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:274 → 294
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:317 → 339
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    15199045..15207982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093243.2 → XP_038949171.1  fez family zinc finger protein 2 isoform X1

    UniProtKB/TrEMBL
    A6K089, B4F7C0, F7ERI8
    Conserved Domains (4) summary
    COG5048
    Location:284 → 390
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:380 → 436
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:274 → 294
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:317 → 339
    zf-H2C2_2; Zinc-finger double domain

  2. XM_039093242.2 → XP_038949170.1  fez family zinc finger protein 2 isoform X1

    UniProtKB/TrEMBL
    A6K089, B4F7C0, F7ERI8
    Conserved Domains (4) summary
    COG5048
    Location:284 → 390
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:380 → 436
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:274 → 294
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:317 → 339
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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