ldb2a LIM domain binding 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ldb2aprovided by ZNC
Official Full Name: LIM domain binding 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-136
See related: Ensembl:ENSDARG00000019579 AllianceGenome:ZFIN:ZDB-GENE-990415-136
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ldb2
Summary: Enables chromatin binding activity. Acts upstream of or within negative regulation of BMP signaling pathway; negative regulation of nodal signaling pathway; and sprouting angiogenesis. Is expressed in several structures, including blood island; cardiovascular system; nervous system; posterior lateral mesoderm; and yolk syncytial layer. Orthologous to human LDB2 (LIM domain binding 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (46683118..46832825, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (47696664..47845744, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The regulation of DLL4 by the LDB2 complex provides a novel mechanism of DLL4 transcriptional control that may be exploited to develop therapeutics for aberrant vascular remodeling.
Title: LDB2 regulates the expression of DLL4 through the formation of oligomeric complexes in endothelial cells.
The fine tuning of TGF-beta signaling derives from positive and negative control by Ldb2a.
Title: A novel TGFβ modulator that uncouples R-Smad/I-Smad-mediated negative feedback from R-Smad/ligand-driven positive feedback.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of nodal signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: LIM domain-binding protein 2a

Names: LIM-domain binding factor 2; LIM-domain binding factor 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131314.1 → NP_571389.1 LIM domain-binding protein 2a

See identical proteins and their annotated locations for NP_571389.1

Status: PROVISIONAL

Source sequence(s)

AF031376

UniProtKB/TrEMBL

O73713

Related

ENSDARP00000124510.1, ENSDART00000149571.3

Conserved Domains (1) summary

pfam01803
Location:31 → 232

LIM_bind; LIM-domain binding protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

46683118..46832825 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005157342.5 → XP_005157399.3 LIM domain-binding protein 2a isoform X1

UniProtKB/TrEMBL

A0A8M2B3G5

Conserved Domains (1) summary

pfam01803
Location:31 → 232

LIM_bind; LIM-domain binding protein