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Ap5m1 adaptor related protein complex 5 subunit mu 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305861, updated on 27-Nov-2024

Summary

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Official Symbol
Ap5m1provided by RGD
Official Full Name
adaptor related protein complex 5 subunit mu 1provided by RGD
Primary source
RGD:1308087
See related
EnsemblRapid:ENSRNOG00000014148 AllianceGenome:RGD:1308087
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mu5; Mudeng; RGD1308087
Summary
Predicted to be involved in endosomal transport. Predicted to be located in membrane. Predicted to be part of AP-type membrane coat adaptor complex. Predicted to be active in cytosol; late endosome; and lysosome. Orthologous to human AP5M1 (adaptor related protein complex 5 subunit mu 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 137.4), Thymus (RPKM 128.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ap5m1 in Genome Data Viewer
Location:
15p14
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (24835122..24864854)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (22355478..22385222)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (25933483..25955745)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene biogenesis of ribosomes BRX1, pseudogene 2 Neighboring gene exocyst complex component 5 Neighboring gene N(alpha)-acetyltransferase 30, NatC catalytic subunit Neighboring gene coiled-coil domain containing 198

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The fifth adaptor protein complex. Hirst J, et al. PLoS Biol, 2011 Oct. PMID 22022230, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC124703

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endosomal transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-type membrane coat adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AP-type membrane coat adaptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of AP-type membrane coat adaptor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
AP-5 complex subunit mu-1
Names
MHD domain-containing death-inducing protein
MU-2/AP1M2 domain containing, death-inducing
adapter-related protein complex 5 mu subunit
adapter-related protein complex 5 subunit mu-1
adaptor-related protein complex 5, mu 1 subunit
mu-2-related death-inducing protein
muD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030036.1 → NP_001025207.1  AP-5 complex subunit mu-1

    See identical proteins and their annotated locations for NP_001025207.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099829
    UniProtKB/Swiss-Prot
    Q499N2
    UniProtKB/TrEMBL
    A0A8L2Q9R9, A6KE84
    Related
    ENSRNOP00000106654.1, ENSRNOT00000126250.1
    Conserved Domains (1) summary
    cd09256
    Location:196 → 482
    AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    24835122..24864854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093286.2 → XP_038949214.1  AP-5 complex subunit mu-1 isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q9R9
    Related
    ENSRNOP00000090061.2, ENSRNOT00000096073.2
    Conserved Domains (1) summary
    cd09256
    Location:196 → 470
    AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

  2. XM_039093287.2 → XP_038949215.1  AP-5 complex subunit mu-1 isoform X2

    Conserved Domains (1) summary
    cl10970
    Location:196 → 316
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

RNA

  1. XR_005493717.2 RNA Sequence

  2. XR_010057813.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q499N2.1 GenPept UniProtKB/Swiss-Prot:Q499N2

Gene LinkOut

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