myl7 myosin, light chain 7, regulatory [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: myl7provided by ZNC
Official Full Name: myosin, light chain 7, regulatoryprovided by ZNC
Primary source: ZFIN:ZDB-GENE-991019-3
See related: Ensembl:ENSDARG00000019096 AllianceGenome:ZFIN:ZDB-GENE-991019-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mlc7; cmlc2; mylc2a; zgc:92755
Summary: Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including cardiac muscle cell proliferation; heart contraction; and myofibril assembly. Predicted to be active in myofibril. Is expressed in several structures, including cardiac muscle myoblast; heart primordium; mesoderm; muscle; and pericardial region. Orthologous to human MYL7 (myosin light chain 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (40457107..40464935, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (40417522..40425350, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

There are distinct roles for cmlc1 and cmlc2 during zebrafish cardiogenesis.
Title: Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms.
Cmlc2 was cloned and a germ-line transmitted zebrafish generated with a GFP gene expressed in myocardial cells around the heart chambers and AV canal.
Title: Germ-line transmission of a myocardium-specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within atrial cardiac myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle tissue development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular cardiac myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in myofibril	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myosin regulatory light chain 2, atrial isoform

Names: cardiac myosin light chain 2; myosin light chain, regulatory A; myosin, light polypeptide 7, regulatory; tel; tell tale heart

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131329.3 → NP_571404.1 myosin regulatory light chain 2, atrial isoform

See identical proteins and their annotated locations for NP_571404.1

Status: PROVISIONAL

Source sequence(s)

BC076232

UniProtKB/TrEMBL

Q6DGV6, Q801M3

Related

ENSDARP00000040012.2, ENSDART00000040013.3

Conserved Domains (2) summary

COG5126
Location:18 → 165

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cl08302
Location:103 → 164

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...