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Piwil2 piwi-like RNA-mediated gene silencing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306011, updated on 27-Nov-2024

Summary

Official Symbol
Piwil2provided by RGD
Official Full Name
piwi-like RNA-mediated gene silencing 2provided by RGD
Primary source
RGD:1306964
See related
EnsemblRapid:ENSRNOG00000009871 AllianceGenome:RGD:1306964
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA endonuclease activity; mRNA binding activity; and piRNA binding activity. Predicted to be involved in several processes, including germ-line stem cell population maintenance; negative regulation of circadian rhythm; and regulation of gene expression. Predicted to act upstream of with a positive effect on piRNA-mediated retrotransposon silencing by heterochromatin formation. Predicted to act upstream of or within positive regulation of meiosis I. Predicted to be located in cytoplasmic ribonucleoprotein granule; dense body; and perinucleolar chromocenter. Predicted to be part of PET complex. Predicted to be active in P granule and nucleus. Orthologous to human PIWIL2 (piwi like RNA-mediated gene silencing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 130.6), Heart (RPKM 65.6) and 1 other tissue See more
Orthologs
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Genomic context

See Piwil2 in Genome Data Viewer
Location:
15p11
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (51841104..51907729, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (45431402..45498034, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (52037693..52116277, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 3 catalytic subunit gamma Neighboring gene mitochondrial pyruvate carrier 1-like Neighboring gene solute carrier family 39 member 14 Neighboring gene histone deacetylase 1-like Neighboring gene small nucleolar RNA SNORA70 Neighboring gene transfer RNA proline (anticodon AGG) 23 Neighboring gene RNA polymerase III subunit D

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables piRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables piRNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in germ-line stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in oogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in piRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in piRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in piRNA-mediated gene silencing by mRNA destabilization IEA
Inferred from Electronic Annotation
more info
 
involved_in piRNA-mediated gene silencing by mRNA destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of meiosis I ISO
Inferred from Sequence Orthology
more info
 
involved_in regulatory ncRNA-mediated gene silencing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulatory ncRNA-mediated gene silencing ISO
Inferred from Sequence Orthology
more info
 
involved_in secondary piRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_positive_effect transposable element silencing by heterochromatin formation ISO
Inferred from Sequence Orthology
more info
 
involved_in transposable element silencing by mRNA destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in transposable element silencing by piRNA-mediated DNA methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in transposable element silencing by piRNA-mediated DNA methylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_positive_effect transposable element silencing by piRNA-mediated heterochromatin formation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in P granule ISO
Inferred from Sequence Orthology
more info
 
part_of PET complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromatoid body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dense body ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinucleolar chromocenter ISO
Inferred from Sequence Orthology
more info
 
located_in pi-body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
piwi-like protein 2
Names
piwi like homolog 2
piwi-like 2
NP_001100746.1
XP_006252333.2
XP_008769050.1
XP_063130372.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107276.1NP_001100746.1  piwi-like protein 2

    See identical proteins and their annotated locations for NP_001100746.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473951
    UniProtKB/TrEMBL
    A6HTK3, D3ZRE1
    Related
    ENSRNOP00000013284.2, ENSRNOT00000013284.6
    Conserved Domains (3) summary
    cd02845
    Location:385502
    PAZ_piwi_like; PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the ...
    cd04658
    Location:510954
    Piwi_piwi-like_Euk; PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of related ...
    pfam08699
    Location:337384
    ArgoL1; Argonaute linker 1 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    51841104..51907729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008770828.4XP_008769050.1  piwi-like protein 2 isoform X2

    Conserved Domains (4) summary
    cd02845
    Location:419536
    PAZ_piwi_like; PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the ...
    cd04658
    Location:544950
    Piwi_piwi-like_Euk; Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of ...
    pfam08699
    Location:371418
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:250346
    ArgoN; N-terminal domain of argonaute
  2. XM_006252271.4XP_006252333.2  piwi-like protein 2 isoform X1

    Related
    ENSRNOP00000105865.1, ENSRNOT00000140972.1
    Conserved Domains (4) summary
    cd02845
    Location:419536
    PAZ_piwi_like; PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the ...
    cd04658
    Location:544988
    Piwi_piwi-like_Euk; Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of ...
    pfam08699
    Location:371418
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:250346
    ArgoN; N-terminal domain of argonaute
  3. XM_063274302.1XP_063130372.1  piwi-like protein 2 isoform X3