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Lcp1 lymphocyte cytosolic protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306071, updated on 27-Nov-2024

Summary

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Official Symbol
Lcp1provided by RGD
Official Full Name
lymphocyte cytosolic protein 1provided by RGD
Primary source
RGD:1308288
See related
EnsemblRapid:ENSRNOG00000010319 AllianceGenome:RGD:1308288
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase binding activity; actin filament binding activity; and integrin binding activity. Involved in animal organ regeneration. Predicted to be located in several cellular components, including actin cytoskeleton; focal adhesion; and ruffle. Predicted to be active in actin filament; actin filament bundle; and cytoplasm. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human LCP1 (lymphocyte cytosolic protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 1086.5), Thymus (RPKM 762.0) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lcp1 in Genome Data Viewer
Location:
15q11
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (56846375..56954090)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (50443300..50544682)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (57170566..57277811)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeats and calponin homology domain containing 1 Neighboring gene uncharacterized LOC134482151 Neighboring gene uncharacterized LOC108352942 Neighboring gene rubicon like autophagy enhancer Neighboring gene uncharacterized LOC120097039 Neighboring gene leucine rich repeat containing 63 Neighboring gene establishment of cohesion 1 homolog 2 (S. cerevisiae), pseudogene 2 Neighboring gene tRNA methyltransferase 10A, pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene carboxypeptidase B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inhibition of the Glycolysis Prevents the Cerebral Infarction Progression Through Decreasing the Lactylation Levels of LCP1. Zhang W, et al. Mol Biotechnol, 2023 Aug. PMID 36574182, Free PMC Article
  2. LCP1 up-regulated by partial pancreatectomy supports cell proliferation and differentiation. Choi JH, et al. Mol Biosyst, 2011 Nov. PMID 21922118
  3. Proteomic analysis of differential protein expression in early process of pancreatic regeneration in pancreatectomized rats. Yang M, et al. Acta Pharmacol Sin, 2006 May. PMID 16626512
  4. Phosphorylation on Ser5 increases the F-actin-binding activity of L-plastin and promotes its targeting to sites of actin assembly in cells. Janji B, et al. J Cell Sci, 2006 May 1. PMID 16636079
  5. Costimulation induced phosphorylation of L-plastin facilitates surface transport of the T cell activation molecules CD69 and CD25. Wabnitz GH, et al. Eur J Immunol, 2007 Mar. PMID 17294403

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of the Glycolysis Prevents the Cerebral Infarction Progression Through Decreasing the Lactylation Levels of LCP1.
    Title: Inhibition of the Glycolysis Prevents the Cerebral Infarction Progression Through Decreasing the Lactylation Levels of LCP1.
  2. the LCP1 may play a critical role in the pancreas regeneration.
    Title: LCP1 up-regulated by partial pancreatectomy supports cell proliferation and differentiation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell activation involved in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament network formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in animal organ regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of podosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in wound healing, spreading of cells ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin filament ISO
Inferred from Sequence Orthology
more info
  
is_active_in actin filament bundle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin filament bundle ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in filopodium ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in glial cell projection ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic cup ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in podosome ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
plastin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012044.1 → NP_001012044.1  plastin-2

    See identical proteins and their annotated locations for NP_001012044.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083855
    UniProtKB/TrEMBL
    A0A8I6AGS0, Q5XI38
    Related
    ENSRNOP00000014502.4, ENSRNOT00000014502.7
    Conserved Domains (5) summary
    smart00033
    Location:398 → 501
    CH; Calponin homology domain
    COG5069
    Location:16 → 620
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00014
    Location:121 → 236
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:13 → 79
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00307
    Location:265 → 370
    CH; Calponin homology (CH) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    56846375..56954090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274316.1 → XP_063130386.1  plastin-2 isoform X1

    UniProtKB/TrEMBL
    Q5XI38
    Related
    ENSRNOP00000071263.2, ENSRNOT00000082191.3

  2. XM_006252319.3 → XP_006252381.1  plastin-2 isoform X1

    See identical proteins and their annotated locations for XP_006252381.1

    UniProtKB/TrEMBL
    A0A8I6AGS0, Q5XI38
    Conserved Domains (5) summary
    smart00033
    Location:398 → 501
    CH; Calponin homology domain
    COG5069
    Location:16 → 620
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00014
    Location:121 → 236
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:13 → 79
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00307
    Location:265 → 370
    CH; Calponin homology (CH) domain
Nucleotide Protein Strain
Heading Accession and Version

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