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Gpr180 G protein-coupled receptor 180 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306165, updated on 4-Jan-2025

Summary

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Official Symbol
Gpr180provided by RGD
Official Full Name
G protein-coupled receptor 180provided by RGD
Primary source
RGD:1359193
See related
EnsemblRapid:ENSRNOG00000009766 AllianceGenome:RGD:1359193
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in G protein-coupled receptor signaling pathway and response to pheromone. Predicted to be located in membrane. Orthologous to human GPR180 (G protein-coupled receptor 180). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 56.6), Brain (RPKM 56.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpr180 in Genome Data Viewer
Location:
15q24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (101602870..101635556)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (95195782..95224955)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (103340387..103369633)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548945 Neighboring gene transfer RNA phenylalanine (anticodon GAA) 5 Neighboring gene TDP-glucose 4,6-dehydratase Neighboring gene uncharacterized LOC134482020 Neighboring gene SRY-box transcription factor 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inhibition of experimental intimal thickening in mice lacking a novel G-protein-coupled receptor. Tsukada S, et al. Circulation, 2003 Jan 21. PMID 12538434
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94555

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in response to pheromone IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
integral membrane protein GPR180
Names
intimal thickness-related receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006994.2 → NP_001006995.1  integral membrane protein GPR180 isoform 1

    See identical proteins and their annotated locations for NP_001006995.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A096MKB1, G3V799, Q5XIJ2
    Conserved Domains (1) summary
    pfam10192
    Location:42 → 304
    GpcrRhopsn4; Rhodopsin-like GPCR transmembrane domain

  2. NM_001415002.1 → NP_001401931.1  integral membrane protein GPR180 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6HUG1
    Related
    ENSRNOP00000013329.5, ENSRNOT00000013329.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    101602870..101635556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017599719.3 → XP_017455208.1  integral membrane protein GPR180 isoform X2

    Related
    ENSRNOP00000101898.1, ENSRNOT00000149070.1

  2. XM_063274349.1 → XP_063130419.1  integral membrane protein GPR180 isoform X1

    Related
    ENSRNOP00000068447.3, ENSRNOT00000077047.4

  3. XM_063274351.1 → XP_063130421.1  integral membrane protein GPR180 isoform X5

  4. XM_063274350.1 → XP_063130420.1  integral membrane protein GPR180 isoform X4

  5. XM_006252455.5 → XP_006252517.1  integral membrane protein GPR180 isoform X3

    Conserved Domains (1) summary
    cl21735
    Location:169 → 329
    Lung_7-TM_R; Lung seven transmembrane receptor

  6. XM_063274352.1 → XP_063130422.1  integral membrane protein GPR180 isoform X6

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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