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Btd biotinidase [ Rattus norvegicus (Norway rat) ]

Gene ID: 306262, updated on 2-Nov-2024

Summary

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Official Symbol
Btdprovided by RGD
Official Full Name
biotinidaseprovided by RGD
Primary source
RGD:1305316
See related
EnsemblRapid:ENSRNOG00000019656 AllianceGenome:RGD:1305316
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable biotinidase activity. Predicted to be involved in biotin metabolic process. Predicted to be located in apical part of cell; nucleolus; and perikaryon. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in biotinidase deficiency. Orthologous to human BTD (biotinidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 149.4), Liver (RPKM 114.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Btd in Genome Data Viewer
Location:
16p16
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (6869448..6900711)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (6863068..6894345)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (7758192..7791301)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene collagen like tail subunit of asymmetric acetylcholinesterase Neighboring gene uncharacterized LOC134482450 Neighboring gene 2-hydroxyacyl-CoA lyase 1 Neighboring gene ankyrin repeat domain 28 Neighboring gene mitochondrial ribosomal protein L37, pseudogene 1 Neighboring gene uncharacterized LOC120097394 Neighboring gene uncharacterized LOC102550037

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Development and characterization of a mouse with profound biotinidase deficiency: a biotin-responsive neurocutaneous disorder. Pindolia K, et al. Mol Genet Metab, 2011 Feb. PMID 21051254, Free PMC Article
  2. Biotinidase reveals the morphogenetic sequence in cochlea and cochlear nucleus of mice. Brumwell CL, et al. Hear Res, 2005 Nov. PMID 16107307
  3. Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Palmer DJ, et al. Proteomics, 2006 Apr. PMID 16502470
  4. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Abonnenc M, et al. Circ Res, 2013 Oct 25. PMID 24006456
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC109548

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables biotinidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biotin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within biotin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in biotin metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
biotinidase
Names
biotinase
NP_001012047.1
XP_006252671.1
XP_006252672.1
XP_006252674.1
XP_006252676.1
XP_006252677.1
XP_006252680.1
XP_006252681.1
XP_006252684.1
XP_017455568.1
XP_038950381.1
XP_038950382.1
XP_038950384.1
XP_038950385.1
XP_038950386.1
XP_063131418.1
XP_063131419.1
XP_063131420.1
XP_063131422.1
XP_063131423.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012047.2 → NP_001012047.1  biotinidase precursor

    See identical proteins and their annotated locations for NP_001012047.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Conserved Domains (2) summary
    cd07567
    Location:36 → 339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371 → 521
    Vanin_C; Vanin C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    6869448..6900711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275348.1 → XP_063131418.1  biotinidase isoform X1

    UniProtKB/TrEMBL
    A0A140TAI2

  2. XM_006252612.3 → XP_006252674.1  biotinidase isoform X2

    See identical proteins and their annotated locations for XP_006252674.1

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Conserved Domains (2) summary
    cd07567
    Location:36 → 339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371 → 521
    Vanin_C; Vanin C-terminal domain

  3. XM_039094456.2 → XP_038950384.1  biotinidase isoform X2

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Conserved Domains (2) summary
    cd07567
    Location:36 → 339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371 → 521
    Vanin_C; Vanin C-terminal domain

  4. XM_006252609.5 → XP_006252671.1  biotinidase isoform X1

    See identical proteins and their annotated locations for XP_006252671.1

    UniProtKB/TrEMBL
    A0A140TAI2
    Related
    ENSRNOP00000109340.1, ENSRNOT00000127104.1
    Conserved Domains (2) summary
    cd07567
    Location:50 → 353
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:385 → 535
    Vanin_C; Vanin C-terminal domain

  5. XM_039094457.2 → XP_038950385.1  biotinidase isoform X2

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Conserved Domains (2) summary
    cd07567
    Location:36 → 339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371 → 521
    Vanin_C; Vanin C-terminal domain

  6. XM_063275350.1 → XP_063131420.1  biotinidase isoform X1

    UniProtKB/TrEMBL
    A0A140TAI2

  7. XM_039094454.2 → XP_038950382.1  biotinidase isoform X2

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Conserved Domains (2) summary
    cd07567
    Location:36 → 339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371 → 521
    Vanin_C; Vanin C-terminal domain

  8. XM_006252619.5 → XP_006252681.1  biotinidase isoform X1

    See identical proteins and their annotated locations for XP_006252681.1

    UniProtKB/TrEMBL
    A0A140TAI2
    Conserved Domains (2) summary
    cd07567
    Location:50 → 353
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:385 → 535
    Vanin_C; Vanin C-terminal domain

  9. XM_017600079.3 → XP_017455568.1  biotinidase isoform X2

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Conserved Domains (2) summary
    cd07567
    Location:36 → 339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371 → 521
    Vanin_C; Vanin C-terminal domain

  10. XM_063275349.1 → XP_063131419.1  biotinidase isoform X1

    UniProtKB/TrEMBL
    A0A140TAI2

  11. XM_006252614.3 → XP_006252676.1  biotinidase isoform X2

    See identical proteins and their annotated locations for XP_006252676.1

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Conserved Domains (2) summary
    cd07567
    Location:36 → 339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371 → 521
    Vanin_C; Vanin C-terminal domain

  12. XM_039094453.2 → XP_038950381.1  biotinidase isoform X1

    UniProtKB/TrEMBL
    A0A140TAI2
    Conserved Domains (2) summary
    cd07567
    Location:50 → 353
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:385 → 535
    Vanin_C; Vanin C-terminal domain

  13. XM_006252622.5 → XP_006252684.1  biotinidase isoform X2

    See identical proteins and their annotated locations for XP_006252684.1

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Conserved Domains (2) summary
    cd07567
    Location:36 → 339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371 → 521
    Vanin_C; Vanin C-terminal domain

  14. XM_006252610.4 → XP_006252672.1  biotinidase isoform X1

    See identical proteins and their annotated locations for XP_006252672.1

    UniProtKB/TrEMBL
    A0A140TAI2
    Conserved Domains (2) summary
    cd07567
    Location:50 → 353
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:385 → 535
    Vanin_C; Vanin C-terminal domain

  15. XM_006252618.4 → XP_006252680.1  biotinidase isoform X2

    See identical proteins and their annotated locations for XP_006252680.1

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Related
    ENSRNOP00000057779.5, ENSRNOT00000061063.6
    Conserved Domains (2) summary
    cd07567
    Location:36 → 339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371 → 521
    Vanin_C; Vanin C-terminal domain

  16. XM_006252615.4 → XP_006252677.1  biotinidase isoform X2

    See identical proteins and their annotated locations for XP_006252677.1

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Conserved Domains (2) summary
    cd07567
    Location:36 → 339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371 → 521
    Vanin_C; Vanin C-terminal domain

  17. XM_039094458.2 → XP_038950386.1  biotinidase isoform X4

    UniProtKB/TrEMBL
    A0A8I6ANH2, A6KFY3
    Related
    ENSRNOP00000100538.1, ENSRNOT00000126690.1
    Conserved Domains (2) summary
    cd07567
    Location:31 → 289
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:321 → 471
    Vanin_C; Vanin C-terminal domain

  18. XM_063275352.1 → XP_063131422.1  biotinidase isoform X2

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Related
    ENSRNOP00000102845.1, ENSRNOT00000128281.1

  19. XM_063275353.1 → XP_063131423.1  biotinidase isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FVF9.1 GenPept UniProtKB/Swiss-Prot:Q5FVF9

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