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Ap1m1 adaptor related protein complex 1 subunit mu 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306332, updated on 4-Jan-2025

Summary

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Official Symbol
Ap1m1provided by RGD
Official Full Name
adaptor related protein complex 1 subunit mu 1provided by RGD
Primary source
RGD:1307653
See related
EnsemblRapid:ENSRNOG00000014454 AllianceGenome:RGD:1307653
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable clathrin adaptor activity. Predicted to be involved in endosome to melanosome transport; melanosome organization; and vesicle-mediated transport. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of clathrin adaptor complex. Predicted to be active in clathrin-coated vesicle and synapse. Orthologous to human AP1M1 (adaptor related protein complex 1 subunit mu 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 151.0), Thymus (RPKM 143.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ap1m1 in Genome Data Viewer
Location:
16p14
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (17620910..17636431, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (17586886..17602410, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19288354..19303818, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 19 open reading frame 44 Neighboring gene calreticulin 3 Neighboring gene epidermal growth factor receptor pathway substrate 15-like 1 Neighboring gene KLF transcription factor 2 Neighboring gene family with sequence similarity 32, member A Neighboring gene calcium and integrin binding family member 3 Neighboring gene hematopoietic SH2 domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Signal-mediated, AP-1/clathrin-dependent sorting of transmembrane receptors to the somatodendritic domain of hippocampal neurons. Farías GG, et al. Neuron, 2012 Sep 6. PMID 22958822, Free PMC Article
  2. mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors. Meyer C, et al. EMBO J, 2000 May 15. PMID 10811610, Free PMC Article
  3. MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids. Morokuma Y, et al. J Biol Chem, 2007 Aug 24. PMID 17604280
  4. AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis. Delevoye C, et al. J Cell Biol, 2009 Oct 19. PMID 19841138, Free PMC Article
  5. Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Hoffert JD, et al. Proc Natl Acad Sci U S A, 2006 May 2. PMID 16641100, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The primary recognition event that underlies somatodendritic sorting contributes to the evolving view of AP-1 as a global regulator of cell polarity.
    Title: Signal-mediated, AP-1/clathrin-dependent sorting of transmembrane receptors to the somatodendritic domain of hippocampal neurons.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC125095

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endosome to melanosome transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endosome to melanosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in melanosome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in melanosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
AP-1 complex subunit mu-1
Names
AP-mu chain family member mu1A
adapter-related protein complex 1 subunit mu-1
adaptor protein complex AP-1 mu-1 subunit
adaptor protein complex AP-1 subunit mu-1
adaptor-related protein complex 1, mu 1 subunit
adaptor-related protein complex AP-1, mu subunit 1
clathrin assembly protein complex 1 medium chain 1
clathrin assembly protein complex 1 mu-1 medium chain 1
golgi adaptor HA1/AP1 adaptin mu-1 subunit
mu-adaptin 1
mu1A-adaptin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044239.2 → NP_001037704.1  AP-1 complex subunit mu-1

    See identical proteins and their annotated locations for NP_001037704.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    Q32Q06
    UniProtKB/TrEMBL
    A0A8I6A2R3, A6K9P8
    Related
    ENSRNOP00000086711.2, ENSRNOT00000115580.2
    Conserved Domains (2) summary
    cd09258
    Location:153 → 422
    AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1
    cd14835
    Location:4 → 142
    AP1_Mu_N; AP-1 complex subunit mu N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    17620910..17636431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094482.2 → XP_038950410.1  AP-1 complex subunit mu-1 isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q9M5
    Related
    ENSRNOP00000019350.5, ENSRNOT00000019350.6
    Conserved Domains (2) summary
    cd09258
    Location:78 → 347
    AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1
    cl38905
    Location:14 → 67
    longin-like; Longin-like domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32Q06.3 GenPept UniProtKB/Swiss-Prot:Q32Q06

Gene LinkOut

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