pth3r parathyroid hormone 3 receptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pth3rprovided by ZNC
Official Full Name: parathyroid hormone 3 receptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-991123-12
See related: Ensembl:ENSDARG00000018418 AllianceGenome:ZFIN:ZDB-GENE-991123-12
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pthr3; pth1rb; zPTH3R
Summary: Enables parathyroid hormone receptor activity and peptide hormone binding activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in bone tissue; gill; liver; muscle; and pleuroperitoneal region. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (9257457..9294819, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (9219614..9256976, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables parathyroid hormone receptor activity	IDA Inferred from Direct Assay more info
enables parathyroid hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IDA Inferred from Direct Assay more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: parathyroid hormone 3 receptor

Names: parathyroid hormone 1 receptor b; parathyroid hormone receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131378.1 → NP_571453.1 parathyroid hormone 3 receptor precursor

See identical proteins and their annotated locations for NP_571453.1

Status: PROVISIONAL

Source sequence(s)

AF132085

UniProtKB/TrEMBL

Q9PVD2

Related

ENSDARP00000027674.6, ENSDART00000003805.7

Conserved Domains (2) summary

cd15983
Location:138 → 415

7tmB1_PTH3R; parathyroid hormone 3 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:61 → 126

HRM; Hormone receptor domain