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Slc25a15 solute carrier family 25 member 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306574, updated on 4-Jan-2025

Summary

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Official Symbol
Slc25a15provided by RGD
Official Full Name
solute carrier family 25 member 15provided by RGD
Primary source
RGD:1311488
See related
EnsemblRapid:ENSRNOG00000011881 AllianceGenome:RGD:1311488
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ornt1; Ab1-114
Summary
Enables L-ornithine transmembrane transporter activity and antiporter activity. Predicted to be involved in L-arginine transmembrane transport; L-lysine transmembrane transport; and mitochondrial L-ornithine transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; citrullinemia; and ornithine translocase deficiency. Orthologous to human SLC25A15 (solute carrier family 25 member 15). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 328.3), Kidney (RPKM 152.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc25a15 in Genome Data Viewer
Location:
16q12.5
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (76334037..76357325)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (69631581..69654869)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (74505318..74554523)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 20 member 2 Neighboring gene small integral membrane protein 19 Neighboring gene uncharacterized LOC120097532 Neighboring gene mitochondrial ribosomal protein S31 Neighboring gene lncRNA derived from hepatocytes Neighboring gene transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 Neighboring gene transfer RNA alanine (anticodon AGC) 82 Neighboring gene SUB1 regulator of transcription, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hormonal induction of hepatic mitochondrial ornithine/citrulline transporter mRNA. Morris SM Jr, et al. Biochem Biophys Res Commun, 2002 Jun 21. PMID 12061769
  2. The purified and reconstituted ornithine/citrulline carrier from rat liver mitochondria: electrical nature and coupling of the exchange reaction with H+ translocation. Indiveri C, et al. Biochem J, 1997 Oct 15. PMID 9359400, Free PMC Article
  3. Three novel mutations (G27E, insAAC, R179X) in the ORNT1 gene of Japanese patients with hyperornithinemia, hyperammonemia, and homocitrullinuria syndrome. Tsujino S, et al. Ann Neurol, 2000 May. PMID 10805333
  4. Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome is caused by mutations in a gene encoding a mitochondrial ornithine transporter. Camacho JA, et al. Nat Genet, 1999 Jun. PMID 10369256
  5. Cloning and characterization of human ORNT2: a second mitochondrial ornithine transporter that can rescue a defective ORNT1 in patients with the hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, a urea cycle disorder. Camacho JA, et al. Mol Genet Metab, 2003 Aug. PMID 12948741

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcriptional Activation of ORNT1 mRNA by dexamethasone in hepatocytes.
    Title: Hormonal induction of hepatic mitochondrial ornithine/citrulline transporter mRNA.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-arginine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-arginine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables L-lysine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-lysine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables L-ornithine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-ornithine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-ornithine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables antiporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-arginine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-arginine transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in L-lysine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-lysine transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in mitochondrial L-ornithine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
mitochondrial ornithine transporter 1
Names
ornithine transporter) member 15
solute carrier family 25 (mitochondrial carrier
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001047880.3 → NP_001041345.1  mitochondrial ornithine transporter 1

    See identical proteins and their annotated locations for NP_001041345.1

    Status: VALIDATED

    Source sequence(s)
    AY325139, CA339807, DY310527
    UniProtKB/TrEMBL
    A0A8I6A3Y8, Q7TPA1
    Related
    ENSRNOP00000072459.2, ENSRNOT00000078971.3
    Conserved Domains (1) summary
    pfam00153
    Location:205 → 332
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    76334037..76357325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094589.1 → XP_038950517.1  mitochondrial ornithine transporter 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A3Y8, Q7TPA1
    Conserved Domains (1) summary
    pfam00153
    Location:205 → 332
    Mito_carr; Mitochondrial carrier protein

  2. XM_006253351.4 → XP_006253413.1  mitochondrial ornithine transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_006253413.1

    UniProtKB/Swiss-Prot
    A0A0G2K309
    UniProtKB/TrEMBL
    A0A8I6A3Y8
    Related
    ENSRNOP00000045952.4, ENSRNOT00000050637.7
    Conserved Domains (1) summary
    pfam00153
    Location:205 → 295
    Mito_carr; Mitochondrial carrier protein

  3. XM_006253350.5 → XP_006253412.1  mitochondrial ornithine transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_006253412.1

    UniProtKB/Swiss-Prot
    A0A0G2K309
    UniProtKB/TrEMBL
    A0A8I6A3Y8
    Conserved Domains (1) summary
    pfam00153
    Location:205 → 295
    Mito_carr; Mitochondrial carrier protein

  4. XM_039094588.2 → XP_038950516.1  mitochondrial ornithine transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    A0A0G2K309
    UniProtKB/TrEMBL
    A0A8I6A3Y8
    Conserved Domains (1) summary
    pfam00153
    Location:205 → 295
    Mito_carr; Mitochondrial carrier protein

  5. XM_006253352.5 → XP_006253414.1  mitochondrial ornithine transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_006253414.1

    UniProtKB/Swiss-Prot
    A0A0G2K309
    UniProtKB/TrEMBL
    A0A8I6A3Y8
    Conserved Domains (1) summary
    pfam00153
    Location:205 → 295
    Mito_carr; Mitochondrial carrier protein

  6. XM_006253353.4 → XP_006253415.1  mitochondrial ornithine transporter 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A3Y8
    Conserved Domains (1) summary
    pfam00153
    Location:173 → 263
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0G2K309.1 GenPept UniProtKB/Swiss-Prot:A0A0G2K309

Gene LinkOut

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