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Tubgcp3 tubulin gamma complex component 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306599, updated on 9-Dec-2024

Summary

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Official Symbol
Tubgcp3provided by RGD
Official Full Name
tubulin gamma complex component 3provided by RGD
Primary source
RGD:1305726
See related
EnsemblRapid:ENSRNOG00000017085 AllianceGenome:RGD:1305726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Predicted to be involved in meiotic cell cycle; microtubule cytoskeleton organization; and mitotic cell cycle. Predicted to be located in cytoplasm and microtubule cytoskeleton. Predicted to be part of gamma-tubulin complex. Orthologous to human TUBGCP3 (tubulin gamma complex component 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 110.9), Adrenal (RPKM 91.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tubgcp3 in Genome Data Viewer
Location:
16q12.5
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (83553950..83614626)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (76851859..76912499)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (82184362..82245041)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ATPase phospholipid transporting 11A Neighboring gene uncharacterized LOC102548949 Neighboring gene uncharacterized LOC134482533 Neighboring gene sperm acrosome associated 7 Neighboring gene uncharacterized LOC120097560

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin. Tassin AM, et al. J Cell Biol, 1998 May 4. PMID 9566969, Free PMC Article
  2. Proteomic analysis of TRPC5- and TRPC6-binding partners reveals interaction with the plasmalemmal Na(+)/K(+)-ATPase. Goel M, et al. Pflugers Arch, 2005 Oct. PMID 16025302
  3. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gamma-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in polar microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
gamma-tubulin complex component 3
Names
tubulin, gamma complex associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107323.2 → NP_001100793.2  gamma-tubulin complex component 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A0G2JUU7, A0A8I6GLP6
    Related
    ENSRNOP00000069236.1, ENSRNOT00000089329.3
    Conserved Domains (2) summary
    pfam04130
    Location:550 → 881
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:246 → 547
    GCP_N_terminal; Gamma tubulin complex component N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    83553950..83614626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275461.1 → XP_063131531.1  gamma-tubulin complex component 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLP6

  2. XM_006253441.5 → XP_006253503.1  gamma-tubulin complex component 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AUJ2, A0A8I6GLP6
    Related
    ENSRNOP00000096034.1, ENSRNOT00000110771.2
    Conserved Domains (1) summary
    pfam04130
    Location:212 → 722
    Spc97_Spc98; Spc97 / Spc98 family
Nucleotide Protein Strain
Heading Accession and Version

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