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tefa TEF transcription factor, PAR bZIP family member a [ Danio rerio (zebrafish) ]

Gene ID: 30674, updated on 4-Jan-2025

Summary

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Official Symbol
tefaprovided by ZNC
Official Full Name
TEF transcription factor, PAR bZIP family member aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-264
See related
Ensembl:ENSDARG00000039117 AllianceGenome:ZFIN:ZDB-GENE-990415-264
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tef; tefb; tefbeta; zTEF[a]; wu:fa12f02; wu:fb11h02
Summary
Predicted to enable DNA-binding transcription factor activity. Acts upstream of or within cellular response to light stimulus and positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in liver; midbrain hindbrain boundary; muscle; pleuroperitoneal region; and visual system. Orthologous to human TEF (TEF transcription factor, PAR bZIP family member). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See tefa in Genome Data Viewer
Location:
chromosome: 12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (19144833..19153224, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (19022959..19031359, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene aconitase 2, mitochondrial Neighboring gene PHD finger protein 5A Neighboring gene zinc finger CCCH-type containing 7Bb Neighboring gene chibby 1, beta catenin antagonist

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Instrument design and protocol for the study of light controlled processes in aquatic organisms, and its application to examine the effect of infrared light on zebrafish. Dekens MP, et al. PLoS One, 2017. PMID 28212399, Free PMC Article
  2. Light directs zebrafish period2 expression via conserved D and E boxes. Vatine G, et al. PLoS Biol, 2009 Oct. PMID 19859524, Free PMC Article
  3. Size-selective mortality induces evolutionary changes in group risk-taking behaviour and the circadian system in a fish. Sbragaglia V, et al. J Anim Ecol, 2021 Feb. PMID 33064849
  4. Contribution of the eye and of opn4xa function to circadian photoentrainment in the diurnal zebrafish. Chaigne C, et al. PLoS Genet, 2024 Feb. PMID 38408087, Free PMC Article
  5. Regulation of per and cry genes reveals a central role for the D-box enhancer in light-dependent gene expression. Mracek P, et al. PLoS One, 2012. PMID 23236462, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TEF regulates light-induced transcription of DNA repair genes.
    Title: Thyrotroph embryonic factor regulates light-induced transcription of repair genes in zebrafish embryonic cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to light stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TEF transcription factor, PAR bZIP family member a
Names
thyrotroph embryonic factor a
thyrotroph embryonic factor beta
thyrotrophic embryonic factor a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431066.1 → NP_001417995.1  TEF transcription factor, PAR bZIP family member a isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX000473
    UniProtKB/TrEMBL
    A0A8M2B278

  2. NM_131400.2 → NP_571475.1  TEF transcription factor, PAR bZIP family member a isoform 2

    See identical proteins and their annotated locations for NP_571475.1

    Status: VALIDATED

    Source sequence(s)
    BX000473
    UniProtKB/TrEMBL
    A0A8N7UZK1, Q9W722
    Related
    ENSDARP00000057123.3, ENSDART00000057124.5
    Conserved Domains (1) summary
    cd14695
    Location:229 → 288
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    19144833..19153224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005156136.4 → XP_005156193.1  TEF transcription factor, PAR bZIP family member a isoform X1

    See identical proteins and their annotated locations for XP_005156193.1

    UniProtKB/TrEMBL
    A0A8M2B252, O57673
    Related
    ENSDARP00000057124.4, ENSDART00000057125.5
    Conserved Domains (1) summary
    cd14695
    Location:216 → 275
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395301.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    368932..375637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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