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Mylip myosin regulatory light chain interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 306825, updated on 27-Nov-2024

Summary

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Official Symbol
Mylipprovided by RGD
Official Full Name
myosin regulatory light chain interacting proteinprovided by RGD
Primary source
RGD:1305761
See related
EnsemblRapid:ENSRNOG00000017579 AllianceGenome:RGD:1305761
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MIR
Summary
Predicted to enable cytoskeletal protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cholesterol homeostasis; negative regulation of low-density lipoprotein particle clearance; and regulation of protein catabolic process. Predicted to be located in cytoplasm; cytoskeleton; and plasma membrane. Orthologous to human MYLIP (myosin regulatory light chain interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 172.9), Thymus (RPKM 158.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mylip in Genome Data Viewer
Location:
17p14
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (19492826..19514490, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (19286649..19308295, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (19682040..19703681, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene guanosine monophosphate reductase Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102549787 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134482828

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Role of PCSK9 and IDOL in the pathogenesis of acquired LDL receptor deficiency and hypercholesterolemia in nephrotic syndrome. Liu S, et al. Nephrol Dial Transplant, 2014 Mar. PMID 24166456
  2. Reciprocal regulation of very low density lipoprotein receptors (VLDLRs) in neurons by brain-derived neurotrophic factor (BDNF) and Reelin: involvement of the E3 ligase Mylip/Idol. Do HT, et al. J Biol Chem, 2013 Oct 11. PMID 23990472, Free PMC Article
  3. Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR. Bornhauser BC, et al. FEBS Lett, 2003 Oct 9. PMID 14550572
  4. MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. Olsson PA, et al. J Biol Chem, 1999 Dec 17. PMID 10593918
  5. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Zelcer N, et al. Science, 2009 Jul 3. PMID 19520913, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LDLR deficiency, hypercholesterolemia and elevated plasma LDL in NS are associated with upregulation of PCSK9 and IDOL.
    Title: Role of PCSK9 and IDOL in the pathogenesis of acquired LDL receptor deficiency and hypercholesterolemia in nephrotic syndrome.
  2. Data indicate that down-regulation of Mylip/Idol using shRNAs abrogated the decrease in VLDLRs induced by Reelin.
    Title: Reciprocal regulation of very low density lipoprotein receptors (VLDLRs) in neurons by brain-derived neurotrophic factor (BDNF) and Reelin: involvement of the E3 ligase Mylip/Idol.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of low-density lipoprotein particle receptor catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MYLIP
Names
RING-type E3 ubiquitin transferase MYLIP
idol
inducible degrader of the LDL-receptor
NP_001100814.2
XP_063132444.1
XP_063132445.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107344.2 → NP_001100814.2  E3 ubiquitin-protein ligase MYLIP

    See identical proteins and their annotated locations for NP_001100814.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    D3ZDI6
    Related
    ENSRNOP00000024021.4, ENSRNOT00000024021.8
    Conserved Domains (4) summary
    smart00295
    Location:5 → 190
    B41; Band 4.1 homologues
    cd13195
    Location:185 → 295
    FERM_C_MYLIP_IDOL; FERM domain C-lobe of E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP; also called inducible degrader of the LDL receptor, IDOL)
    cd16523
    Location:386 → 423
    RING-HC_MYLIP; RING finger, HC subclass, found in myosin regulatory light chain interacting protein (MYLIP) and similar proteins
    cd17104
    Location:1 → 81
    FERM_F1_MYLIP; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in E3 ubiquitin-protein ligase MYLIP and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    19492826..19514490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276374.1 → XP_063132444.1  E3 ubiquitin-protein ligase MYLIP isoform X1

  2. XM_063276375.1 → XP_063132445.1  E3 ubiquitin-protein ligase MYLIP isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZDI6.1 GenPept UniProtKB/Swiss-Prot:D3ZDI6

Gene LinkOut

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