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Carmil1 capping protein regulator and myosin 1 linker 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306941, updated on 2-Nov-2024

Summary

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Official Symbol
Carmil1provided by RGD
Official Full Name
capping protein regulator and myosin 1 linker 1provided by RGD
Primary source
RGD:1306623
See related
EnsemblRapid:ENSRNOG00000016576 AllianceGenome:RGD:1306623
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lrrc16; Lrrc16a
Summary
Predicted to be involved in several processes, including actin filament network formation; plasma membrane bounded cell projection organization; and regulation of actin filament organization. Predicted to be located in several cellular components, including cell leading edge; macropinosome; and nuclear speck. Predicted to be part of filamentous actin. Predicted to be active in lamellipodium and plasma membrane. Orthologous to human CARMIL1 (capping protein regulator and myosin 1 linker 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 137.4), Adrenal (RPKM 135.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Carmil1 in Genome Data Viewer
Location:
17p11
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (41235819..41516204)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (40807921..41088326)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (43050282..43339403)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene adaptor related protein complex 1 subunit beta 1, pseudogene 1 Neighboring gene small ubiquitin-like modifier 1, pseudogene 1 Neighboring gene uncharacterized LOC120097824 Neighboring gene uncharacterized LOC120097823 Neighboring gene uncharacterized LOC100909739 Neighboring gene secretagogin, EF-hand calcium binding protein Neighboring gene H2A clustered histone 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility. Sakiyama M, et al. Hum Cell, 2014 Jan. PMID 24318514, Free PMC Article
  2. Cell Migration and Invadopodia Formation Require a Membrane-binding Domain of CARMIL2. Lanier MH, et al. J Biol Chem, 2016 Jan 15. PMID 26578515, Free PMC Article
  3. Distinct roles for CARMIL isoforms in cell migration. Liang Y, et al. Mol Biol Cell, 2009 Dec. PMID 19846667, Free PMC Article
  4. Mammalian CARMIL inhibits actin filament capping by capping protein. Yang C, et al. Dev Cell, 2005 Aug. PMID 16054028, Free PMC Article
  5. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. Kolz M, et al. PLoS Genet, 2009 Jun. PMID 19503597, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament network formation ISO
Inferred from Sequence Orthology
more info
  
involved_in barbed-end actin filament uncapping ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in macropinocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of barbed-end actin filament capping ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lamellipodium organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ruffle organization ISO
Inferred from Sequence Orthology
more info
  
involved_in urate metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of filamentous actin ISO
Inferred from Sequence Orthology
more info
  
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in macropinosome ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-actin-uncapping protein LRRC16A
Names
leucine rich repeat containing 16
leucine rich repeat containing 16A
leucine-rich repeat-containing protein 16A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191692.1 → NP_001178621.1  F-actin-uncapping protein LRRC16A

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A0G2JXG7, A0A8I6AJW0
    Related
    ENSRNOP00000056268.4, ENSRNOT00000059510.5
    Conserved Domains (4) summary
    cd00116
    Location:229 → 373
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:248 → 275
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:339 → 366
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:790 → 1080
    CARMIL_C; CARMIL C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    41235819..41516204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276423.1 → XP_063132493.1  F-actin-uncapping protein LRRC16A isoform X9

  2. XM_063276428.1 → XP_063132498.1  F-actin-uncapping protein LRRC16A isoform X13

    Related
    ENSRNOP00000081294.2, ENSRNOT00000117749.2

  3. XM_063276429.1 → XP_063132499.1  F-actin-uncapping protein LRRC16A isoform X14

  4. XM_063276430.1 → XP_063132500.1  F-actin-uncapping protein LRRC16A isoform X14

  5. XM_063276420.1 → XP_063132490.1  F-actin-uncapping protein LRRC16A isoform X5

  6. XM_063276421.1 → XP_063132491.1  F-actin-uncapping protein LRRC16A isoform X6

  7. XM_063276431.1 → XP_063132501.1  F-actin-uncapping protein LRRC16A isoform X15

    Related
    ENSRNOP00000099065.1, ENSRNOT00000121246.1

  8. XM_008771642.4 → XP_008769864.2  F-actin-uncapping protein LRRC16A isoform X1

    UniProtKB/TrEMBL
    A0A8I6AJW0

  9. XM_063276422.1 → XP_063132492.1  F-actin-uncapping protein LRRC16A isoform X7

  10. XM_063276425.1 → XP_063132495.1  F-actin-uncapping protein LRRC16A isoform X11

  11. XM_063276426.1 → XP_063132496.1  F-actin-uncapping protein LRRC16A isoform X11

  12. XM_063276427.1 → XP_063132497.1  F-actin-uncapping protein LRRC16A isoform X11

  13. XM_063276418.1 → XP_063132488.1  F-actin-uncapping protein LRRC16A isoform X2

    Related
    ENSRNOP00000085444.2, ENSRNOT00000108358.2

  14. XM_008771644.4 → XP_008769866.2  F-actin-uncapping protein LRRC16A isoform X3

    UniProtKB/TrEMBL
    A0A8I6AJW0
    Related
    ENSRNOP00000095539.2, ENSRNOT00000104932.2

  15. XM_017600541.3 → XP_017456030.1  F-actin-uncapping protein LRRC16A isoform X8

    UniProtKB/TrEMBL
    A0A8I6AJW0
    Related
    ENSRNOP00000070264.3, ENSRNOT00000080745.3

  16. XM_039095698.2 → XP_038951626.1  F-actin-uncapping protein LRRC16A isoform X12

    UniProtKB/TrEMBL
    A0A8I6A2B1, A0A8I6G5R0
    Related
    ENSRNOP00000102732.1, ENSRNOT00000164795.1
    Conserved Domains (6) summary
    PHA02682
    Location:1128 → 1279
    PHA02682; ORF080 virion core protein; Provisional
    sd00031
    Location:248 → 275
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:339 → 366
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:786 → 1076
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:38 → 119
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:281 → 595
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  17. XM_063276419.1 → XP_063132489.1  F-actin-uncapping protein LRRC16A isoform X4

  18. XM_063276424.1 → XP_063132494.1  F-actin-uncapping protein LRRC16A isoform X10

Nucleotide Protein Strain
Heading Accession and Version

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