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Zfp438 zinc finger protein 438 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307024, updated on 14-Nov-2024

Summary

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Official Symbol
Zfp438provided by RGD
Official Full Name
zinc finger protein 438provided by RGD
Primary source
RGD:1307214
See related
EnsemblRapid:ENSRNOG00000028329 AllianceGenome:RGD:1307214
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307214
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ZNF438 (zinc finger protein 438). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 33.3), Testes (RPKM 29.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp438 in Genome Data Viewer
Location:
17q12.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (57121637..57242892)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (52426221..52547472)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (55006893..55131567)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC134482725 Neighboring gene uncharacterized LOC108348574 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 like 3 Neighboring gene uncharacterized LOC108348573 Neighboring gene supervillin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a novel human zinc finger gene, ZNF438, with transcription inhibition activity. Zhong Z, et al. J Biochem Mol Biol, 2007 Jul 31. PMID 17669267
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc finger protein 438

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107358.1 → NP_001100828.1  zinc finger protein 438

    See identical proteins and their annotated locations for NP_001100828.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474030
    UniProtKB/TrEMBL
    A0A8I5ZQC0, A6K9F0, D4ACS2
    Conserved Domains (3) summary
    PHA03269
    Location:88 → 236
    PHA03269; envelope glycoprotein C; Provisional
    sd00017
    Location:494 → 514
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:520 → 542
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    57121637..57242892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276461.1 → XP_063132531.1  zinc finger protein 438 isoform X2

    UniProtKB/TrEMBL
    A6K9F0, D4ACS2

  2. XM_039095727.2 → XP_038951655.1  zinc finger protein 438 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZQC0, A6K9F0, D4ACS2
    Related
    ENSRNOP00000033287.4, ENSRNOT00000033827.7
    Conserved Domains (3) summary
    PHA03269
    Location:88 → 236
    PHA03269; envelope glycoprotein C; Provisional
    sd00017
    Location:494 → 514
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:520 → 542
    zf-C2H2; Zinc finger, C2H2 type

  3. XM_017600559.3 → XP_017456048.1  zinc finger protein 438 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZQC0, A6K9F0, D4ACS2
    Conserved Domains (3) summary
    PHA03269
    Location:88 → 236
    PHA03269; envelope glycoprotein C; Provisional
    sd00017
    Location:494 → 514
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:520 → 542
    zf-C2H2; Zinc finger, C2H2 type

  4. XM_017600557.3 → XP_017456046.1  zinc finger protein 438 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JU08, A0A8I6AA68
    Related
    ENSRNOP00000068915.1, ENSRNOT00000086342.3
    Conserved Domains (2) summary
    sd00017
    Location:497 → 517
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:509 → 534
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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