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Mtpap mitochondrial poly(A) polymerase [ Rattus norvegicus (Norway rat) ]

Gene ID: 307050, updated on 27-Nov-2024

Summary

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Official Symbol
Mtpapprovided by RGD
Official Full Name
mitochondrial poly(A) polymeraseprovided by RGD
Primary source
RGD:1310900
See related
EnsemblRapid:ENSRNOG00000016578 AllianceGenome:RGD:1310900
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Papd1
Summary
Predicted to enable several functions, including metal ion binding activity; poly(A) RNA polymerase activity; and ribonucleotide binding activity. Predicted to be involved in histone mRNA catabolic process and mitochondrial RNA 3'-end processing. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in spastic ataxia 4. Orthologous to human MTPAP (mitochondrial poly(A) polymerase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 90.7), Kidney (RPKM 83.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mtpap in Genome Data Viewer
Location:
17q12.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (58015979..58036735, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (53320739..53341500, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (56046507..56068185, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348576 Neighboring gene uncharacterized LOC120097757 Neighboring gene uncharacterized LOC134482858 Neighboring gene mitogen-activated protein kinase kinase kinase 8 Neighboring gene ribosomal protein L27A like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase. Bai Y, et al. Mol Cell, 2011 Feb 4. PMID 21292163, Free PMC Article
  2. Defective mitochondrial mRNA maturation is associated with spastic ataxia. Crosby AH, et al. Am J Hum Genet, 2010 Nov 12. PMID 20970105, Free PMC Article
  3. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. Mullen TE, et al. Genes Dev, 2008 Jan 1. PMID 18172165, Free PMC Article
  4. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables UTP binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) RNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in histone mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial RNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
poly(A) RNA polymerase, mitochondrial
Names
PAP associated domain containing 1
NP_001386242.1
NP_001386243.1
XP_038951675.1
XP_063132550.1
XP_063132551.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399313.1 → NP_001386242.1  poly(A) RNA polymerase, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    Related
    ENSRNOP00000022462.6, ENSRNOT00000022462.8
    Conserved Domains (3) summary
    cd05402
    Location:209 → 347
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    COG5260
    Location:184 → 496
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
    pfam17797
    Location:63 → 132
    RL; RL domain

  2. NM_001399314.1 → NP_001386243.1  poly(A) RNA polymerase, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    Conserved Domains (3) summary
    cd05402
    Location:205 → 343
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    COG5260
    Location:180 → 492
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
    pfam17797
    Location:59 → 128
    RL; RL domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    58015979..58036735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276480.1 → XP_063132550.1  poly(A) RNA polymerase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I6A369, A6K9G0

  2. XM_063276481.1 → XP_063132551.1  poly(A) RNA polymerase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I6A369, A6K9G0

  3. XM_039095747.2 → XP_038951675.1  poly(A) RNA polymerase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y4F0, A0A8I6A369, A6K9G0
    Related
    ENSRNOP00000076406.1, ENSRNOT00000099525.2
    Conserved Domains (2) summary
    cd05402
    Location:28 → 99
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    COG5260
    Location:57 → 248
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

RNA

  1. XR_005495287.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107359.1: Suppressed sequence

    Description
    NM_001107359.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

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