Akr1c19 aldo-keto reductase family 1, member C19 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Akr1c19provided by RGD
Official Full Name: aldo-keto reductase family 1, member C19provided by RGD
Primary source: RGD:1562954
See related: EnsemblRapid:ENSRNOG00000038319 AllianceGenome:RGD:1562954
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RAKi; RGD1562954
Summary: Predicted to enable bile acid binding activity; ketosteroid monooxygenase activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in glycoside metabolic process; progesterone metabolic process; and prostaglandin metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Liver (RPKM 160.8), Testes (RPKM 94.1) and 9 other tissues See more
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Genomic context

Location:: 17q12.2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (70913916..70934959)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (66001358..66027226)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (69653003..69675204)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of aldo-keto reductase 1C subfamily members encoded in two rat genes (akr1c19 and RGD1564865). Relationship to 9-hydroxyprostaglandin dehydrogenase.
Title: Characterization of aldo-keto reductase 1C subfamily members encoded in two rat genes (akr1c19 and RGD1564865). Relationship to 9-hydroxyprostaglandin dehydrogenase.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables androsterone dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables bile acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables ketosteroid monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in daunorubicin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in doxorubicin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in progesterone metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aldo-keto reductase family 1, member C19

Names: NAD-preferring dehydrogenase for 17beta-hydroxysteroids and 9-hydroxyprostaglandins

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100576.1 → NP_001094046.1 aldo-keto reductase family 1, member C19

See identical proteins and their annotated locations for NP_001094046.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A7I8HPA0, A6JLP3, D3ZEL2

Conserved Domains (1) summary

cd19108
Location:6 → 308

AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

70913916..70934959

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095774.2 → XP_038951702.1 aldo-keto reductase family 1, member C19 isoform X1

UniProtKB/TrEMBL

A0A7I8HPA0, A6JLP3, D3ZEL2

Related

ENSRNOP00000055152.1, ENSRNOT00000058351.3

Conserved Domains (1) summary

cd19108
Location:6 → 308

AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)