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Gramd2b GRAM domain containing 2B [ Rattus norvegicus (Norway rat) ]

Gene ID: 307288, updated on 2-Nov-2024

Summary

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Official Symbol
Gramd2bprovided by RGD
Official Full Name
GRAM domain containing 2Bprovided by RGD
Primary source
RGD:1311016
See related
EnsemblRapid:ENSRNOG00000015225 AllianceGenome:RGD:1311016
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gramd3; RGD1311016
Summary
Predicted to enable identical protein binding activity. Predicted to be located in membrane. Predicted to be active in cytoplasmic microtubule. Orthologous to human GRAMD2B (GRAM domain containing 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 152.3), Brain (RPKM 75.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gramd2b in Genome Data Viewer
Location:
18q11-q12.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (52082128..52180056)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (49884014..49981955)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (51492196..51591028)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S9, pseudogene 6 Neighboring gene cofilin 1, pseudogene 3 Neighboring gene uncharacterized LOC120098295 Neighboring gene voltage-dependent anion channel 1, pseudogene 11 Neighboring gene aldehyde dehydrogenase 7 family, member A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. Fong KW, et al. J Cell Sci, 2013 Feb 1. PMID 23264731, Free PMC Article
  2. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109479

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GRAM domain-containing protein 2B
Names
GRAM domain containing 3
GRAM domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014011.1 → NP_001014033.1  GRAM domain-containing protein 2B

    See identical proteins and their annotated locations for NP_001014033.1

    Status: PROVISIONAL

    Source sequence(s)
    BC090001
    UniProtKB/Swiss-Prot
    Q5FVG8
    UniProtKB/TrEMBL
    A0A8I5ZT46, A6IX52, A6IX54
    Related
    ENSRNOP00000020570.5, ENSRNOT00000020570.8
    Conserved Domains (1) summary
    cd13220
    Location:135 → 227
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    52082128..52180056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254748.5 → XP_006254810.1  GRAM domain-containing protein 2B isoform X1

    See identical proteins and their annotated locations for XP_006254810.1

    UniProtKB/TrEMBL
    A0A0G2K8Q2, A0A8I5ZT46, A6IX53, A6IX54
    Related
    ENSRNOP00000074694.2, ENSRNOT00000078518.3
    Conserved Domains (1) summary
    cd13220
    Location:122 → 214
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

  2. XM_063277299.1 → XP_063133369.1  GRAM domain-containing protein 2B isoform X2

    UniProtKB/TrEMBL
    A0A8I6APU9
    Related
    ENSRNOP00000095800.1, ENSRNOT00000117795.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FVG8.1 GenPept UniProtKB/Swiss-Prot:Q5FVG8

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