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Cep120 centrosomal protein 120 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307302, updated on 2-Nov-2024

Summary

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Official Symbol
Cep120provided by RGD
Official Full Name
centrosomal protein 120provided by RGD
Primary source
RGD:1565619
See related
EnsemblRapid:ENSRNOG00000017035 AllianceGenome:RGD:1565619
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ccdc100; RGD1565619
Summary
Predicted to be involved in several processes, including interkinetic nuclear migration; positive regulation of cilium assembly; and regulation of centrosome duplication. Predicted to act upstream of or within several processes, including astral microtubule organization; nervous system development; and regulation of microtubule-based process. Predicted to be located in centriole. Predicted to be active in centrosome. Human ortholog(s) of this gene implicated in Joubert syndrome 31 and short-rib thoracic dysplasia 13 with or without polydactyly. Orthologous to human CEP120 (centrosomal protein 120). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 131.9), Lung (RPKM 111.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cep120 in Genome Data Viewer
Location:
18q11
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (49326266..49388380, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (47127979..47189964, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (48658495..48720570, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase C Neighboring gene PR/SET domain 6 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134483022 Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 2 Neighboring gene casein kinase 1, gamma 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Talpid3-binding centrosomal protein Cep120 is required for centriole duplication and proliferation of cerebellar granule neuron progenitors. Wu C, et al. PLoS One, 2014. PMID 25251415, Free PMC Article
  2. The transcription factor XBP-1 is essential for the development and survival of dendritic cells. Iwakoshi NN, et al. J Exp Med, 2007 Oct 1. PMID 17875675, Free PMC Article
  3. CEP295 interacts with microtubules and is required for centriole elongation. Chang CW, et al. J Cell Sci, 2016 Jul 1. PMID 27185865, Free PMC Article
  4. Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool. Xie Z, et al. Neuron, 2007 Oct 4. PMID 17920017, Free PMC Article
  5. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within astral microtubule organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebral cortex development ISO
Inferred from Sequence Orthology
more info
  
involved_in interkinetic nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within interkinetic nuclear migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neurogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of centriole elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of centriole elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of centrosome duplication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of establishment of protein localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of microtubule-based process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centrosomal protein of 120 kDa
Names
centrosomal protein 120kDa
coiled-coil domain containing 100

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191697.1 → NP_001178626.1  centrosomal protein of 120 kDa

    See identical proteins and their annotated locations for NP_001178626.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A6IX35, D4A3J3
    Related
    ENSRNOP00000023236.6, ENSRNOT00000023236.8
    Conserved Domains (5) summary
    cd00030
    Location:531 → 564
    C2; C2 domain
    cl02553
    Location:703 → 928
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam12416
    Location:118 → 340
    DUF3668; Cep120 protein
    pfam17045
    Location:667 → 920
    CEP63; Centrosomal protein of 63 kDa
    cl14603
    Location:9 → 114
    C2; C2 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    49326266..49388380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277302.1 → XP_063133372.1  centrosomal protein of 120 kDa isoform X1

    UniProtKB/TrEMBL
    D4A3J3

  2. XM_063277305.1 → XP_063133375.1  centrosomal protein of 120 kDa isoform X4

  3. XM_063277303.1 → XP_063133373.1  centrosomal protein of 120 kDa isoform X2

  4. XM_063277304.1 → XP_063133374.1  centrosomal protein of 120 kDa isoform X3

RNA

  1. XR_010059566.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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