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Ablim3 actin binding LIM protein family, member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307395, updated on 4-Jan-2025

Summary

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Official Symbol
Ablim3provided by RGD
Official Full Name
actin binding LIM protein family, member 3provided by RGD
Primary source
RGD:1565118
See related
EnsemblRapid:ENSRNOG00000019365 AllianceGenome:RGD:1565118
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565118
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in cilium assembly; lamellipodium assembly; and positive regulation of protein targeting to mitochondrion. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in lamellipodium. Predicted to be active in glutamatergic synapse and stress fiber. Orthologous to human ABLIM3 (actin binding LIM protein family member 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 106.2), Heart (RPKM 71.2) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ablim3 in Genome Data Viewer
Location:
18q12.1
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (57527917..57646936, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (55256135..55376629, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (57126534..57245965, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482948 Neighboring gene GrpE-like 2, mitochondrial Neighboring gene actin filament associated protein 1-like 1 Neighboring gene uncharacterized LOC120098202 Neighboring gene uncharacterized LOC134483038

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. abLIM3 is a novel component of adherens junctions with actin-binding activity. Matsuda M, et al. Eur J Cell Biol, 2010 Nov. PMID 20709423
  2. Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. Barrientos T, et al. J Biol Chem, 2007 Mar 16. PMID 17194709
  3. miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Cao J, et al. Nat Cell Biol, 2012 Jun 10. PMID 22684256
  4. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Hasson SA, et al. Nature, 2013 Dec 12. PMID 24270810, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
actin-binding LIM protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191698.1 → NP_001178627.1  actin-binding LIM protein 3

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A0G2K875, A0A8I6AVJ1
    Related
    ENSRNOP00000074499.2, ENSRNOT00000080365.3
    Conserved Domains (6) summary
    smart00153
    Location:648 → 683
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:151 → 202
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:210 → 265
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:274 → 647
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    57527917..57646936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277351.1 → XP_063133421.1  actin-binding LIM protein 3 isoform X6

    UniProtKB/TrEMBL
    A6IXJ1

  2. XM_063277347.1 → XP_063133417.1  actin-binding LIM protein 3 isoform X2

    UniProtKB/TrEMBL
    A6IXJ1

  3. XM_063277350.1 → XP_063133420.1  actin-binding LIM protein 3 isoform X5

    UniProtKB/TrEMBL
    A6IXJ1

  4. XM_063277349.1 → XP_063133419.1  actin-binding LIM protein 3 isoform X4

    UniProtKB/TrEMBL
    A6IXJ1
    Related
    ENSRNOP00000026227.4, ENSRNOT00000026227.8

  5. XM_063277348.1 → XP_063133418.1  actin-binding LIM protein 3 isoform X3

    UniProtKB/TrEMBL
    A6IXJ1

  6. XM_063277353.1 → XP_063133423.1  actin-binding LIM protein 3 isoform X8

    UniProtKB/TrEMBL
    A0A8I6A3Y2
    Related
    ENSRNOP00000087213.2, ENSRNOT00000107734.2

  7. XM_063277352.1 → XP_063133422.1  actin-binding LIM protein 3 isoform X7

    UniProtKB/TrEMBL
    A0A8I6ABY0

  8. XM_063277346.1 → XP_063133416.1  actin-binding LIM protein 3 isoform X1

    UniProtKB/TrEMBL
    A6IXJ1
Nucleotide Protein Strain
Heading Accession and Version

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