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Tcerg1 transcription elongation regulator 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307474, updated on 27-Nov-2024

Summary

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Official Symbol
Tcerg1provided by RGD
Official Full Name
transcription elongation regulator 1provided by RGD
Primary source
RGD:1311748
See related
EnsemblRapid:ENSRNOG00000018849 AllianceGenome:RGD:1311748
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ca150
Summary
Predicted to enable several functions, including enzyme binding activity; identical protein binding activity; and proline-rich region binding activity. Predicted to be involved in RNA processing and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human TCERG1 (transcription elongation regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 224.0), Spleen (RPKM 208.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tcerg1 in Genome Data Viewer
Location:
18p11
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (34756558..34817441)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (34505708..34566470)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (36796290..36889966)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene POU class 4 homeobox 3 Neighboring gene G protein-coupled receptor 151 Neighboring gene ubiquitin-40S ribosomal protein S27a pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity. Arango M, et al. J Neurosci, 2006 Apr 26. PMID 16641246, Free PMC Article
  2. General structural motifs of amyloid protofilaments. Ferguson N, et al. Proc Natl Acad Sci U S A, 2006 Oct 31. PMID 17060612, Free PMC Article
  3. Structural characterization of a new binding motif and a novel binding mode in group 2 WW domains. Ramirez-Espain X, et al. J Mol Biol, 2007 Nov 9. PMID 17915251
  4. Transcription elongation regulator 1 is a co-integrator of the cell fate determination factor Dachshund homolog 1. Zhou J, et al. J Biol Chem, 2010 Dec 17. PMID 20956529, Free PMC Article
  5. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables proline-rich region binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like protein conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription elongation regulator 1
Names
coactivator of 150 kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107390.2 → NP_001100860.2  transcription elongation regulator 1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I6GKL3, D3ZTL0
    Related
    ENSRNOP00000025467.5, ENSRNOT00000025467.8
    Conserved Domains (4) summary
    smart00441
    Location:938 → 993
    FF; Contains two conserved F residues
    smart00456
    Location:132 → 164
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:416 → 445
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam01846
    Location:777 → 826
    FF; FF domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    34756558..34817441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254673.5 → XP_006254735.1  transcription elongation regulator 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GKL3
    Related
    ENSRNOP00000073243.2, ENSRNOT00000086979.3
    Conserved Domains (5) summary
    smart00441
    Location:955 → 1010
    FF; Contains two conserved F residues
    cl14654
    Location:827 → 905
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00456
    Location:132 → 164
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:416 → 445
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam01846
    Location:794 → 843
    FF; FF domain

  2. XM_039096854.2 → XP_038952782.1  transcription elongation regulator 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6GKL3
    Conserved Domains (4) summary
    COG5104
    Location:404 → 934
    PRP40; Splicing factor [RNA processing and modification]
    pfam05109
    Location:239 → 327
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00397
    Location:137 → 162
    WW; WW domain
    pfam01846
    Location:960 → 1019
    FF; FF domain

  3. XM_063277363.1 → XP_063133433.1  transcription elongation regulator 1 isoform X6

  4. XM_006254674.5 → XP_006254736.1  transcription elongation regulator 1 isoform X2

    See identical proteins and their annotated locations for XP_006254736.1

    UniProtKB/TrEMBL
    A0A8I6GKL3, B5DEZ4
    Conserved Domains (4) summary
    smart00441
    Location:934 → 989
    FF; Contains two conserved F residues
    smart00456
    Location:132 → 164
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:395 → 424
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam01846
    Location:773 → 822
    FF; FF domain

  5. XM_006254675.5 → XP_006254737.1  transcription elongation regulator 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AM46, A0A8I6GKL3
    Related
    ENSRNOP00000094971.1, ENSRNOT00000116807.2
    Conserved Domains (4) summary
    smart00441
    Location:917 → 972
    FF; Contains two conserved F residues
    smart00456
    Location:132 → 164
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:395 → 424
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam01846
    Location:756 → 805
    FF; FF domain

  6. XM_017600960.3 → XP_017456449.2  transcription elongation regulator 1 isoform X5

    Conserved Domains (4) summary
    smart00441
    Location:698 → 753
    FF; Contains two conserved F residues
    PHA03247
    Location:21 → 161
    PHA03247; large tegument protein UL36; Provisional
    COG5104
    Location:147 → 625
    PRP40; Splicing factor [RNA processing and modification]
    pfam01846
    Location:641 → 692
    FF; FF domain

  7. XM_039096855.2 → XP_038952783.1  transcription elongation regulator 1 isoform X7

    Conserved Domains (3) summary
    smart00441
    Location:486 → 541
    FF; Contains two conserved F residues
    COG5104
    Location:48 → 413
    PRP40; Splicing factor [RNA processing and modification]
    pfam01846
    Location:429 → 480
    FF; FF domain

RNA

  1. XR_361332.5 RNA Sequence

  2. XR_005496033.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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