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Psd2 pleckstrin and Sec7 domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307500, updated on 9-Dec-2024

Summary

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Official Symbol
Psd2provided by RGD
Official Full Name
pleckstrin and Sec7 domain containing 2provided by RGD
Primary source
RGD:1311075
See related
EnsemblRapid:ENSRNOG00000019177 AllianceGenome:RGD:1311075
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and phospholipid binding activity. Predicted to be involved in regulation of ARF protein signal transduction. Predicted to be located in several cellular components, including cleavage furrow; neuronal cell body; and ruffle membrane. Predicted to be active in glutamatergic synapse and postsynapse. Orthologous to human PSD2 (pleckstrin and Sec7 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 63.0) and Kidney (RPKM 2.3) See more
Orthologs
human mouse all
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Genomic context

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See Psd2 in Genome Data Viewer
Location:
18p11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (27838943..27890712)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (27564912..27616674)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (28781267..28832429)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551758 Neighboring gene uncharacterized LOC134483009 Neighboring gene neuregulin 2 Neighboring gene uncharacterized LOC120098187 Neighboring gene purine rich element binding protein A Neighboring gene IgA-inducing protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells. Matsuya S, et al. J Neurochem, 2005 May. PMID 15836626
  2. EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis. Ueda T, et al. FEBS Lett, 2013 Jun 5. PMID 23603394

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
PH and SEC7 domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107395.1 → NP_001100865.1  PH and SEC7 domain-containing protein 2

    See identical proteins and their annotated locations for NP_001100865.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473974
    UniProtKB/TrEMBL
    A6J301
    Related
    ENSRNOP00000026112.6, ENSRNOT00000026112.7
    Conserved Domains (3) summary
    cd00171
    Location:295 → 462
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    cd13295
    Location:508 → 631
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
    pfam00169
    Location:528 → 623
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    27838943..27890712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277371.1 → XP_063133441.1  PH and SEC7 domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A6J301

  2. XM_039096865.2 → XP_038952793.1  PH and SEC7 domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    D4ACB6
    Conserved Domains (2) summary
    cd00171
    Location:295 → 463
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    cd13295
    Location:509 → 632
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

  3. XM_039096866.2 → XP_038952794.1  PH and SEC7 domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    D4ACB6
    Conserved Domains (2) summary
    cd00171
    Location:295 → 463
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    cd13295
    Location:509 → 632
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

RNA

  1. XR_005496039.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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