U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sap130 Sin3A associated protein 130 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307527, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Sap130provided by RGD
Official Full Name
Sin3A associated protein 130provided by RGD
Primary source
RGD:1311657
See related
EnsemblRapid:ENSRNOG00000016773 AllianceGenome:RGD:1311657
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311657
Summary
Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be part of Sin3-type complex. Orthologous to human SAP130 (Sin3A associated protein 130). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 45.8), Thymus (RPKM 44.5) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Sap130 in Genome Data Viewer
Location:
18p12
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (23518773..23619840)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (23244337..23345368)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (24397523..24497831)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35 like 1 Neighboring gene uncharacterized LOC134482923 Neighboring gene solute carrier family 25, member 46 Neighboring gene AMMECR1 like Neighboring gene uncharacterized LOC100910201 Neighboring gene RNA polymerase II subunit D

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Sin3a repressor complex is a master regulator of STAT transcriptional activity. Icardi L, et al. Proc Natl Acad Sci U S A, 2012 Jul 24. PMID 22783022, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
histone deacetylase complex subunit SAP130
NP_001414044.1
XP_006254667.1
XP_006254668.1
XP_006254669.1
XP_017456575.1
XP_038953244.1
XP_038953245.1
XP_063133456.1
XP_063133457.1
XP_063133458.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427115.1 → NP_001414044.1  histone deacetylase complex subunit SAP130

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    D3ZLP9
    Related
    ENSRNOP00000022761.8, ENSRNOT00000022761.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    23518773..23619840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254605.4 → XP_006254667.1  histone deacetylase complex subunit SAP130 isoform X1

    See identical proteins and their annotated locations for XP_006254667.1

    UniProtKB/TrEMBL
    D3ZLP9
    Related
    ENSRNOP00000112150.1, ENSRNOT00000163641.1
    Conserved Domains (1) summary
    pfam16014
    Location:649 → 1054
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

  2. XM_006254606.5 → XP_006254668.1  histone deacetylase complex subunit SAP130 isoform X2

    See identical proteins and their annotated locations for XP_006254668.1

    Conserved Domains (1) summary
    pfam16014
    Location:648 → 1053
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

  3. XM_017601086.3 → XP_017456575.1  histone deacetylase complex subunit SAP130 isoform X5

  4. XM_039097317.2 → XP_038953245.1  histone deacetylase complex subunit SAP130 isoform X7

    Conserved Domains (2) summary
    PHA03247
    Location:7 → 352
    PHA03247; large tegument protein UL36; Provisional
    pfam05109
    Location:243 → 527
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  5. XM_063277386.1 → XP_063133456.1  histone deacetylase complex subunit SAP130 isoform X4

  6. XM_063277388.1 → XP_063133458.1  histone deacetylase complex subunit SAP130 isoform X6

  7. XM_063277387.1 → XP_063133457.1  histone deacetylase complex subunit SAP130 isoform X4

    Related
    ENSRNOP00000107068.1, ENSRNOT00000138732.1

  8. XM_039097316.2 → XP_038953244.1  histone deacetylase complex subunit SAP130 isoform X3

    UniProtKB/TrEMBL
    D3ZLP9
    Conserved Domains (2) summary
    PHA03247
    Location:55 → 493
    PHA03247; large tegument protein UL36; Provisional
    pfam16014
    Location:636 → 1041
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

  9. XM_006254607.5 → XP_006254669.1  histone deacetylase complex subunit SAP130 isoform X3

    See identical proteins and their annotated locations for XP_006254669.1

    UniProtKB/TrEMBL
    D3ZLP9
    Conserved Domains (2) summary
    PHA03247
    Location:55 → 493
    PHA03247; large tegument protein UL36; Provisional
    pfam16014
    Location:636 → 1041
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools