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Cables1 Cdk5 and Abl enzyme substrate 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307585, updated on 27-Nov-2024

Summary

Official Symbol
Cables1provided by RGD
Official Full Name
Cdk5 and Abl enzyme substrate 1provided by RGD
Primary source
RGD:1305516
See related
EnsemblRapid:ENSRNOG00000012795 AllianceGenome:RGD:1305516
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in nervous system development. Predicted to be active in cytosol. Orthologous to human CABLES1 (Cdk5 and Abl enzyme substrate 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 87.9), Brain (RPKM 53.9) and 9 other tissues See more
Orthologs
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Genomic context

See Cables1 in Genome Data Viewer
Location:
18p13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (3349681..3455956)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (3076556..3181181)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (3317724..3421721)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene U6 snRNA-associated Sm-like protein LSm3 Neighboring gene RB binding protein 8, endonuclease Neighboring gene uncharacterized LOC134482975 Neighboring gene solute carrier family 25 member 19, pseudogene 1 Neighboring gene transmembrane protein 241 Neighboring gene uncharacterized LOC120098160 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CDK5 and ABL1 enzyme substrate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107404.2NP_001100874.2  CDK5 and ABL1 enzyme substrate 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    F1LUR9
    Related
    ENSRNOP00000017187.7, ENSRNOT00000017187.8
  2. NM_001415691.1NP_001402620.1  CDK5 and ABL1 enzyme substrate 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I6AIM6
    Related
    ENSRNOP00000094903.1, ENSRNOT00000104819.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    3349681..3455956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096929.2XP_038952857.1  CDK5 and ABL1 enzyme substrate 1 isoform X1

  2. XM_039096930.2XP_038952858.1  CDK5 and ABL1 enzyme substrate 1 isoform X1

  3. XM_063277454.1XP_063133524.1  CDK5 and ABL1 enzyme substrate 1 isoform X2