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Mib1 MIB E3 ubiquitin protein ligase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307594, updated on 27-Nov-2024

Summary

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Official Symbol
Mib1provided by RGD
Official Full Name
MIB E3 ubiquitin protein ligase 1provided by RGD
Primary source
RGD:1307195
See related
EnsemblRapid:ENSRNOG00000013281 AllianceGenome:RGD:1307195
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including Notch signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within several processes, including chordate embryonic development; circulatory system development; and positive regulation of endocytosis. Predicted to be located in centrosome and cytoplasmic vesicle. Predicted to be active in cytoplasm; glutamatergic synapse; and postsynaptic density. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Orthologous to human MIB1 (MIB E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 302.0), Kidney (RPKM 285.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mib1 in Genome Data Viewer
Location:
18p13
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (2075309..2199774)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (1802519..1926988)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (1970914..2094920)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nuclear ribonucleoprotein D1 polypeptide Neighboring gene abhydrolase domain containing 3, phospholipase Neighboring gene histidine-rich glycoprotein-like Neighboring gene small nucleolar RNA SNORA70 Neighboring gene microRNA 133a-1 Neighboring gene microRNA 3582 Neighboring gene microRNA 3571 Neighboring gene UBA-like domain containing 2, pseudogene 1 Neighboring gene microRNA 1 Neighboring gene uncharacterized LOC108348742 Neighboring gene uncharacterized LOC108348741 Neighboring gene uncharacterized LOC134482974

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. E3 ubiquitin ligase mind bomb 1 overexpression reduces apoptosis and inflammation of cardiac microvascular endothelial cells in coronary microvascular dysfunction. Qin XF, et al. Cell Signal, 2022 Mar. PMID 34954392
  2. The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein. Kwon DY, et al. Mol Biol Cell, 2013 Jun. PMID 23615451, Free PMC Article
  3. Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Itoh M, et al. Dev Cell, 2003 Jan. PMID 12530964
  4. Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1. Choe EA, et al. J Neurosci, 2007 Aug 29. PMID 17728463, Free PMC Article
  5. Mind bomb 1 is essential for generating functional Notch ligands to activate Notch. Koo BK, et al. Development, 2005 Aug. PMID 16000382

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E3 ubiquitin ligase mind bomb 1 overexpression reduces apoptosis and inflammation of cardiac microvascular endothelial cells in coronary microvascular dysfunction.
    Title: E3 ubiquitin ligase mind bomb 1 overexpression reduces apoptosis and inflammation of cardiac microvascular endothelial cells in coronary microvascular dysfunction.
  2. Mib1 analysis provides a comprehensive interactome for investigating its role in signaling networks and neuronal development.
    Title: Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within blood vessel development ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart looping ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within somitogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MIB1
Names
mindbomb E3 ubiquitin protein ligase 1
mindbomb homolog 1
NP_001100875.1
XP_038952859.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107405.2 → NP_001100875.1  E3 ubiquitin-protein ligase MIB1

    See identical proteins and their annotated locations for NP_001100875.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A6KNF0, D3ZUV2
    Related
    ENSRNOP00000018025.6, ENSRNOT00000018025.8
    Conserved Domains (9) summary
    PHA03095
    Location:439 → 710
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:83 → 127
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:562 → 593
    ANK; ANK repeat [structural motif]
    cd16724
    Location:818 → 854
    RING1-HC_MIB1; RING finger 1, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
    cd16725
    Location:865 → 901
    RING2-HC_MIB1; RING finger 2, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
    cd16727
    Location:962 → 1003
    RING3-HC_MIB1; RING finger 3, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
    pfam06701
    Location:154 → 218
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:670 → 770
    Ank_2; Ankyrin repeats (3 copies)
    pfam18346
    Location:333 → 397
    SH3_15; Mind bomb SH3 repeat domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    2075309..2199774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096931.2 → XP_038952859.1  E3 ubiquitin-protein ligase MIB1 isoform X1

    UniProtKB/TrEMBL
    A6KNF0, D3ZUV2
    Conserved Domains (9) summary
    PHA03095
    Location:439 → 710
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:83 → 127
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:562 → 593
    ANK; ANK repeat [structural motif]
    cd16724
    Location:818 → 854
    RING1-HC_MIB1; RING finger 1, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
    cd16725
    Location:865 → 901
    RING2-HC_MIB1; RING finger 2, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
    cd16727
    Location:962 → 1003
    RING3-HC_MIB1; RING finger 3, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
    pfam06701
    Location:154 → 218
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:670 → 770
    Ank_2; Ankyrin repeats (3 copies)
    pfam18346
    Location:333 → 397
    SH3_15; Mind bomb SH3 repeat domain
Nucleotide Protein Strain
Heading Accession and Version

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