Acd ACD, shelterin complex subunit and telomerase recruitment factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acdprovided by RGD
Official Full Name: ACD, shelterin complex subunit and telomerase recruitment factorprovided by RGD
Primary source: RGD:1565053
See related: EnsemblRapid:ENSRNOG00000038973 AllianceGenome:RGD:1565053
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA polymerase binding activity; telomerase inhibitor activity; and telomeric DNA binding activity. Predicted to be involved in several processes, including establishment of protein localization; negative regulation of telomere maintenance via telomerase; and telomere organization. Predicted to act upstream of or within several processes, including embryonic limb morphogenesis; telomere maintenance; and urogenital system development. Predicted to be located in chromosome, telomeric region and nuclear body. Predicted to be part of shelterin complex. Human ortholog(s) of this gene implicated in autosomal dominant dyskeratosis congenita 6. Orthologous to human ACD (ACD shelterin complex subunit and telomerase recruitment factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 96.8), Spleen (RPKM 76.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (50496634..50499397, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (33586739..33589481, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (37665289..37668043, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitoribosomal Deregulation Drives Senescence via TPP1-Mediated Telomere Deprotection.
Title: Mitoribosomal Deregulation Drives Senescence via TPP1-Mediated Telomere Deprotection.

Submit: New GeneRIF Correction

General gene information

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Markers

RH128404 (e-PCR)
- UniSTS:211712

RH132532 (e-PCR)
- UniSTS:215815

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA polymerase binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables telomerase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables telomerase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomeric DNA binding	IEA Inferred from Electronic Annotation more info
enables telomeric DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in embryonic limb morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic limb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to telomere	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to telomere	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomere maintenance via telomerase	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of telomere maintenance via telomerase	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in protection from non-homologous end joining at telomere	IEA Inferred from Electronic Annotation more info
involved_in protection from non-homologous end joining at telomere	ISO Inferred from Sequence Orthology more info
involved_in protein localization to chromosome, telomeric region	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
involved_in regulation of establishment of protein localization to telomere	IEA Inferred from Electronic Annotation more info
involved_in regulation of establishment of protein localization to telomere	ISO Inferred from Sequence Orthology more info
involved_in segmentation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within segmentation	ISO Inferred from Sequence Orthology more info
involved_in skeletal system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in telomere assembly	IEA Inferred from Electronic Annotation more info
involved_in telomere assembly	ISO Inferred from Sequence Orthology more info
involved_in telomere capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere capping	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via telomerase	IEA Inferred from Electronic Annotation more info
involved_in telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in urogenital system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within urogenital system development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
part_of nuclear telomere cap complex	ISO Inferred from Sequence Orthology more info
part_of shelterin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of shelterin complex	IEA Inferred from Electronic Annotation more info
part_of shelterin complex	ISO Inferred from Sequence Orthology more info
part_of telomerase holoenzyme complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adrenocortical dysplasia protein homolog

Names: adrenocortical dysplasia homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037193.1 → NP_001032270.1 adrenocortical dysplasia protein homolog

See identical proteins and their annotated locations for NP_001032270.1

Status: PROVISIONAL

Source sequence(s)

BC099222

UniProtKB/Swiss-Prot

Q4FZR5

UniProtKB/TrEMBL

A6IYR6

Conserved Domains (1) summary

pfam10341
Location:11 → 118

TPP1; Shelterin complex subunit, TPP1/ACD

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

50496634..50499397 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008772496.4 → XP_008770718.1 adrenocortical dysplasia protein homolog isoform X1

UniProtKB/TrEMBL

A0A8L2QTF0

Related

ENSRNOP00000056334.3, ENSRNOT00000059577.4

Conserved Domains (1) summary

pfam10341
Location:11 → 118

TPP1; Shelterin complex subunit, TPP1/ACD