Nfat5 nuclear factor of activated T-cells 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nfat5provided by RGD
Official Full Name: nuclear factor of activated T-cells 5provided by RGD
Primary source: RGD:1309142
See related: EnsemblRapid:ENSRNOG00000011879 AllianceGenome:RGD:1309142
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nfat; NF-AT5; TonEBP
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in several processes, including R-loop processing; calcineurin-NFAT signaling cascade; and positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within positive regulation of gene expression and regulation of calcineurin-NFAT signaling cascade. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human NFAT5 (nuclear factor of activated T cells 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 325.0), Kidney (RPKM 246.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (52108982..52196418)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (35199737..35286675)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (38446059..38533735, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRPA1 deficiency attenuates cardiac fibrosis via regulating GRK5/NFAT signaling in diabetic rats.
Title: TRPA1 deficiency attenuates cardiac fibrosis via regulating GRK5/NFAT signaling in diabetic rats.
LncRNA CCAT1 Protects Astrocytes Against OGD/R-Induced Damage by Targeting the miR-218/NFAT5-Signaling Axis.
Title: LncRNA CCAT1 Protects Astrocytes Against OGD/R-Induced Damage by Targeting the miR-218/NFAT5-Signaling Axis.
NFAT5 promotes arteriogenesis via MCP-1-dependent monocyte recruitment.
Title: NFAT5 promotes arteriogenesis via MCP-1-dependent monocyte recruitment.
ANGII increases Annexin-A2 nucleic acid-binding activity and elevates protein levels of the NFAT5 transcription factor in kidneys of hypertensive rats.
Title: NFAT5 regulates renal gene expression in response to angiotensin II through Annexin-A2-mediated posttranscriptional regulation in hypertensive rats.
the present results suggested that the AngII/TRPC6/NFAT axis may be a crucial signaling pathway in podocytes that is necessary for maintaining the integrity of the glomerular filtration barrier
Title: Participation of the AngII/TRPC6/NFAT axis in the pathogenesis of podocyte injury in rats with type 2 diabetes.
our results suggest that increases in extracellular osmolarity and TonEBP do not play a role in controlling autophagy in NP cells.
Title: Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus.
TonEBP expression correlated with canonical osmoregulatory targets TauT/SLC6A6, SMIT/SLC5A3, and AR/AKR1B1, supporting in vitro findings that the inflammatory milieu during IDD does not interfere with TonEBP osmoregulation. In summary, whereas TonEBP participates in the proinflammatory response to TNF-alpha
Title: TNF-α promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells.
Together these results show that the expression of TonEBP is regulated by inflammatory signals in mammalian brain, suggesting that TonEBP might play a part during neuroinflammation.
Title: Inflammatory signals induce the expression of tonicity-responsive enhancer binding protein (TonEBP) in microglia.
NFAT5 serves an important pathophysiological role in seawater inhalationinduced acute lung injury by modulating NFkappaB activity.
Title: NFAT5 participates in seawater inhalation‑induced acute lung injury via modulation of NF-κB activity.
Overexpression of NFAT5 promoted survival of the astrocytes and SIRT1 activation under oxygen-glucose-serum deprivation/restoration damage and inhibited cell apoptosis.
Title: NFAT5 protects astrocytes against oxygen-glucose-serum deprivation/restoration damage via the SIRT1/Nrf2 pathway.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D19Got27 (e-PCR)
- UniSTS:114728

RH133372 (e-PCR)
- UniSTS:216655

RH142814 (e-PCR)
- UniSTS:232061

UniSTS:224902 (e-PCR)
- UniSTS:224902

AU027125 (e-PCR)
- UniSTS:113610

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in R-loop processing	ISO Inferred from Sequence Orthology more info
involved_in R-loop processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcineurin-NFAT signaling cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nuclear factor of activated T-cells 5

Names: T-cell transcription factor NFAT5; nuclear factor of activated T-cells 5, tonicity-responsive

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107425.1 → NP_001100895.1 nuclear factor of activated T-cells 5

See identical proteins and their annotated locations for NP_001100895.1

Status: PROVISIONAL

Source sequence(s)

CH473972

UniProtKB/Swiss-Prot

D3ZGB1

UniProtKB/TrEMBL

A0A8I6ANN3

Related

ENSRNOP00000017005.3, ENSRNOT00000017005.7

Conserved Domains (2) summary

cd07882
Location:297 → 457

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:461 → 560

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

52108982..52196418

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008772503.4 → XP_008770725.1 nuclear factor of activated T-cells 5 isoform X1

UniProtKB/TrEMBL

A0A8I6ANN3

Conserved Domains (2) summary

cd07882
Location:297 → 457

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:461 → 560

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
XM_003751872.6 → XP_003751920.1 nuclear factor of activated T-cells 5 isoform X2

UniProtKB/TrEMBL

A0A8I5ZWM0, A0A8I6ANN3

Related

ENSRNOP00000083454.1, ENSRNOT00000094607.2

Conserved Domains (2) summary

cd07882
Location:279 → 439

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:443 → 542

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
XM_063278043.1 → XP_063134113.1 nuclear factor of activated T-cells 5 isoform X3
XM_063278044.1 → XP_063134114.1 nuclear factor of activated T-cells 5 isoform X4
XM_039097749.2 → XP_038953677.1 nuclear factor of activated T-cells 5 isoform X5

UniProtKB/TrEMBL

A0A8I6ANN3, A6IYZ9

Conserved Domains (3) summary

TIGR01628
Location:1196 → 1294

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd07882
Location:204 → 364

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:368 → 467

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
XM_063278045.1 → XP_063134115.1 nuclear factor of activated T-cells 5 isoform X6
XM_006255556.5 → XP_006255618.1 nuclear factor of activated T-cells 5 isoform X6

See identical proteins and their annotated locations for XP_006255618.1

UniProtKB/TrEMBL

A0A8I6ANN3

Conserved Domains (3) summary

TIGR01628
Location:1065 → 1163

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd07882
Location:73 → 233

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:237 → 336

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
XM_017601291.3 → XP_017456780.1 nuclear factor of activated T-cells 5 isoform X5

UniProtKB/TrEMBL

A0A8I6ANN3, A6IYZ9

Conserved Domains (3) summary

TIGR01628
Location:1196 → 1294

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd07882
Location:204 → 364

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:368 → 467

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
XM_006255555.5 → XP_006255617.1 nuclear factor of activated T-cells 5 isoform X6

See identical proteins and their annotated locations for XP_006255617.1

UniProtKB/TrEMBL

A0A8I6ANN3

Conserved Domains (3) summary

TIGR01628
Location:1065 → 1163

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd07882
Location:73 → 233

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:237 → 336

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
XM_063278046.1 → XP_063134116.1 nuclear factor of activated T-cells 5 isoform X7
XM_008772505.4 → XP_008770727.1 nuclear factor of activated T-cells 5 isoform X6

See identical proteins and their annotated locations for XP_008770727.1

UniProtKB/TrEMBL

A0A8I6ANN3

Conserved Domains (3) summary

TIGR01628
Location:1065 → 1163

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd07882
Location:73 → 233

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:237 → 336

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
XM_039097751.2 → XP_038953679.1 nuclear factor of activated T-cells 5 isoform X8

UniProtKB/TrEMBL

A0A8I6ANN3

Conserved Domains (3) summary

TIGR01628
Location:1048 → 1146

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd07882
Location:56 → 216

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:220 → 319

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
XM_039097752.2 → XP_038953680.1 nuclear factor of activated T-cells 5 isoform X9

UniProtKB/TrEMBL

A0A8I6ANN3

Conserved Domains (3) summary

TIGR01628
Location:1005 → 1103

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd07882
Location:13 → 173

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cd01178
Location:177 → 276

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.