Chst4 carbohydrate sulfotransferase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chst4provided by RGD
Official Full Name: carbohydrate sulfotransferase 4provided by RGD
Primary source: RGD:1310798
See related: EnsemblRapid:ENSRNOG00000016953 AllianceGenome:RGD:1310798
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable N-acetylglucosamine 6-O-sulfotransferase activity. Predicted to be involved in N-acetylglucosamine metabolic process; positive regulation of leukocyte tethering or rolling; and sulfur compound metabolic process. Predicted to act upstream of or within leukocyte tethering or rolling and protein sulfation. Predicted to be located in Golgi membrane. Predicted to be active in trans-Golgi network. Orthologous to human CHST4 (carbohydrate sulfotransferase 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Uterus (RPKM 64.6), Lung (RPKM 17.1) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (54900914..54911735, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (37993471..38002123, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (41630060..41642373)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acetylglucosamine 6-O-sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetylglucosamine 6-O-sulfotransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in N-acetylglucosamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-acetylglucosamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein sulfation	ISO Inferred from Sequence Orthology more info
involved_in sulfur compound metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfur compound metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carbohydrate sulfotransferase 4

Names: carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4; carbohydrate (chondroitin 6/keratan) sulfotransferase 4

NP_001100897.1

EC 2.8.2.-

XP_063134124.1

EC 2.8.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107427.3 → NP_001100897.1 carbohydrate sulfotransferase 4

See identical proteins and their annotated locations for NP_001100897.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A6IZ48, D3ZLS2

Conserved Domains (1) summary

cl21551
Location:181 → 354

Sulfotransfer_1; Sulfotransferase domain
NM_001434437.1 → NP_001421366.1 carbohydrate sulfotransferase 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A6IZ48, D3ZLS2