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Ablim1 actin-binding LIM protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307989, updated on 4-Jan-2025

Summary

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Symbol
Ablim1provided by RGD
Full Name
actin-binding LIM protein 1provided by RGD
Primary source
RGD:1565768
See related
EnsemblRapid:ENSRNOG00000046333 AllianceGenome:RGD:1565768
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565768
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in cilium assembly and lamellipodium assembly. Predicted to act upstream of or within axon guidance and positive regulation of transcription by RNA polymerase II. Predicted to be located in lamellipodium. Predicted to be active in postsynaptic density and stress fiber. Orthologous to human ABLIM1 (actin binding LIM protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 402.2), Thymus (RPKM 205.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ablim1 in Genome Data Viewer
Location:
1q55
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (266088868..266377169, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (256083747..256372075, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (277853877..278043096, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene von Willebrand factor A domain containing 2 Neighboring gene actin filament associated protein 1-like 2 Neighboring gene uncharacterized LOC134485257 Neighboring gene uncharacterized LOC120100065 Neighboring gene uncharacterized LOC120100066 Neighboring gene uncharacterized LOC134485258

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein. Roof DJ, et al. J Cell Biol, 1997 Aug 11. PMID 9245787, Free PMC Article
  2. A POU domain transcription factor-dependent program regulates axon pathfinding in the vertebrate visual system. Erkman L, et al. Neuron, 2000 Dec. PMID 11163266
  3. Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. Barrientos T, et al. J Biol Chem, 2007 Mar 16. PMID 17194709
  4. miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Cao J, et al. Nat Cell Biol, 2012 Jun 10. PMID 22684256
  5. Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. Leonoudakis D, et al. J Biol Chem, 2004 May 21. PMID 15024025

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC125264

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
actin-binding LIM protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395154.1 → NP_001382083.1  actin-binding LIM protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5Y6A1, A0A8I5ZVV8
    Related
    ENSRNOP00000076718.2, ENSRNOT00000106287.2
    Conserved Domains (5) summary
    smart00153
    Location:828 → 863
    VHP; Villin headpiece domain
    cd09327
    Location:100 → 151
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:156 → 211
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:227 → 278
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:286 → 341
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins

  2. NM_001395155.1 → NP_001382084.1  actin-binding LIM protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2JW01, Q3KR72
    Related
    ENSRNOP00000069687.3, ENSRNOT00000078416.3
    Conserved Domains (3) summary
    smart00153
    Location:392 → 427
    VHP; Villin headpiece domain
    pfam16182
    Location:33 → 391
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    266088868..266377169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110220.2 → XP_038966148.1  actin-binding LIM protein 1 isoform X31

    UniProtKB/TrEMBL
    A0A8I6A592
    Related
    ENSRNOP00000089021.2, ENSRNOT00000108182.2
    Conserved Domains (6) summary
    smart00153
    Location:734 → 769
    VHP; Villin headpiece domain
    cd09327
    Location:60 → 111
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:116 → 171
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:187 → 238
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:246 → 301
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:338 → 733
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  2. XM_039110327.2 → XP_038966255.1  actin-binding LIM protein 1 isoform X32

    UniProtKB/TrEMBL
    A0A8I5ZVV8
    Related
    ENSRNOP00000082920.2, ENSRNOT00000094452.2
    Conserved Domains (6) summary
    smart00153
    Location:723 → 758
    VHP; Villin headpiece domain
    cd09327
    Location:126 → 177
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:182 → 237
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:253 → 304
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:312 → 367
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:376 → 722
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  3. XM_039110316.2 → XP_038966244.1  actin-binding LIM protein 1 isoform X30

    UniProtKB/TrEMBL
    A0A8I5ZVV8
    Conserved Domains (6) summary
    smart00153
    Location:743 → 778
    VHP; Villin headpiece domain
    cd09327
    Location:99 → 150
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:155 → 210
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:226 → 277
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:285 → 340
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:349 → 742
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  4. XM_063288242.1 → XP_063144312.1  actin-binding LIM protein 1 isoform X27

  5. XM_063288169.1 → XP_063144239.1  actin-binding LIM protein 1 isoform X6

    UniProtKB/TrEMBL
    F1LWK7

  6. XM_063288185.1 → XP_063144255.1  actin-binding LIM protein 1 isoform X9

    UniProtKB/TrEMBL
    F1LWK7

  7. XM_063288152.1 → XP_063144222.1  actin-binding LIM protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A592

  8. XM_063288149.1 → XP_063144219.1  actin-binding LIM protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A592

  9. XM_063288164.1 → XP_063144234.1  actin-binding LIM protein 1 isoform X4

    UniProtKB/TrEMBL
    F1LWK7

  10. XM_063288167.1 → XP_063144237.1  actin-binding LIM protein 1 isoform X5

    UniProtKB/TrEMBL
    F1LWK7

  11. XM_063288159.1 → XP_063144229.1  actin-binding LIM protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A592

  12. XM_063288172.1 → XP_063144242.1  actin-binding LIM protein 1 isoform X7

    UniProtKB/TrEMBL
    F1LWK7

  13. XM_063288216.1 → XP_063144286.1  actin-binding LIM protein 1 isoform X16

    UniProtKB/TrEMBL
    F1LWK7

  14. XM_063288221.1 → XP_063144291.1  actin-binding LIM protein 1 isoform X18

    UniProtKB/TrEMBL
    F1LWK7

  15. XM_063288189.1 → XP_063144259.1  actin-binding LIM protein 1 isoform X10

    UniProtKB/TrEMBL
    F1LWK7

  16. XM_063288194.1 → XP_063144264.1  actin-binding LIM protein 1 isoform X11

    UniProtKB/TrEMBL
    F1LWK7

  17. XM_063288206.1 → XP_063144276.1  actin-binding LIM protein 1 isoform X14

    UniProtKB/TrEMBL
    F1LWK7

  18. XM_063288177.1 → XP_063144247.1  actin-binding LIM protein 1 isoform X8

    UniProtKB/TrEMBL
    F1LWK7

  19. XM_063288202.1 → XP_063144272.1  actin-binding LIM protein 1 isoform X12

    UniProtKB/TrEMBL
    F1LWK7

  20. XM_063288205.1 → XP_063144275.1  actin-binding LIM protein 1 isoform X13

    UniProtKB/TrEMBL
    F1LWK7

  21. XM_063288219.1 → XP_063144289.1  actin-binding LIM protein 1 isoform X17

    UniProtKB/TrEMBL
    F1LWK7

  22. XM_063288210.1 → XP_063144280.1  actin-binding LIM protein 1 isoform X15

    UniProtKB/TrEMBL
    F1LWK7

  23. XM_063288237.1 → XP_063144307.1  actin-binding LIM protein 1 isoform X25

    UniProtKB/TrEMBL
    F1LWK7

  24. XM_063288226.1 → XP_063144296.1  actin-binding LIM protein 1 isoform X19

    UniProtKB/TrEMBL
    F1LWK7

  25. XM_063288235.1 → XP_063144305.1  actin-binding LIM protein 1 isoform X24

    UniProtKB/TrEMBL
    F1LWK7

  26. XM_063288228.1 → XP_063144298.1  actin-binding LIM protein 1 isoform X21

    UniProtKB/TrEMBL
    F1LWK7

  27. XM_063288233.1 → XP_063144303.1  actin-binding LIM protein 1 isoform X22

    UniProtKB/TrEMBL
    F1LWK7

  28. XM_063288227.1 → XP_063144297.1  actin-binding LIM protein 1 isoform X20

    UniProtKB/TrEMBL
    F1LWK7

  29. XM_039110273.2 → XP_038966201.1  actin-binding LIM protein 1 isoform X23

    Conserved Domains (5) summary
    cd09327
    Location:60 → 111
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:116 → 171
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:187 → 238
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:246 → 301
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:354 → 576
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  30. XM_039110288.2 → XP_038966216.1  actin-binding LIM protein 1 isoform X26

    Conserved Domains (5) summary
    cd09327
    Location:60 → 111
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:116 → 171
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:187 → 238
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:246 → 301
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:354 → 501
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  31. XM_039110296.2 → XP_038966224.1  actin-binding LIM protein 1 isoform X28

    Conserved Domains (5) summary
    cd09327
    Location:60 → 111
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:116 → 171
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:187 → 238
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:246 → 301
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:354 → 431
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  32. XM_063288249.1 → XP_063144319.1  actin-binding LIM protein 1 isoform X29

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001044394.1: Suppressed sequence

    Description
    NM_001044394.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.

  2. NM_001372054.2: Suppressed sequence

    Description
    NM_001372054.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
Nucleotide Protein Strain
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