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Brd9 bromodomain containing 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308067, updated on 27-Nov-2024

Summary

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Official Symbol
Brd9provided by RGD
Official Full Name
bromodomain containing 9provided by RGD
Primary source
RGD:1307359
See related
EnsemblRapid:ENSRNOG00000015676 AllianceGenome:RGD:1307359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable lysine-acetylated histone binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of SWI/SNF complex. Predicted to be active in nucleus. Orthologous to human BRD9 (bromodomain containing 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 86.6), Lung (RPKM 81.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Brd9 in Genome Data Viewer
Location:
1p11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (31158546..31185812, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (29329981..29357285, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (31939612..31968120, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene tubulin polymerization promoting protein Neighboring gene zinc finger, DHHC-type containing 11 Neighboring gene uncharacterized LOC134484978 Neighboring gene small nucleolar RNA SNORA21 Neighboring gene thyroid hormone receptor interactor 13 Neighboring gene NKD inhibitor of WNT signaling pathway 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. BRD9 Inhibition Attenuates Matrix Degradation and Pyroptosis in Nucleus Pulposus by Modulating the NOX1/ROS/NF-κB axis. Deng Z, et al. Inflammation, 2023 Jun. PMID 36801999
  2. Histone recognition and large-scale structural analysis of the human bromodomain family. Filippakopoulos P, et al. Cell, 2012 Mar 30. PMID 22464331, Free PMC Article
  3. ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Hargreaves DC, et al. Cell Res, 2011 Mar. PMID 21358755, Free PMC Article
  4. Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. Alpsoy A, et al. J Biol Chem, 2018 Mar 16. PMID 29374058, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BRD9 Inhibition Attenuates Matrix Degradation and Pyroptosis in Nucleus Pulposus by Modulating the NOX1/ROS/NF-kappaB axis.
    Title: BRD9 Inhibition Attenuates Matrix Degradation and Pyroptosis in Nucleus Pulposus by Modulating the NOX1/ROS/NF-κB axis.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lysine-acetylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysine-acetylated histone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SWI/SNF complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bromodomain-containing protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395085.1 → NP_001382014.1  bromodomain-containing protein 9 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6JUV9
    Conserved Domains (1) summary
    cd05513
    Location:140 → 237
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...

  2. NM_001395087.1 → NP_001382016.1  bromodomain-containing protein 9 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6JUW0, D4ACF5
    Related
    ENSRNOP00000021000.9, ENSRNOT00000021000.9
    Conserved Domains (1) summary
    cd05513
    Location:140 → 237
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...

  3. NM_001395088.1 → NP_001382017.1  bromodomain-containing protein 9 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6JUV9
    Conserved Domains (1) summary
    cd05513
    Location:137 → 234
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...

  4. NM_001395089.1 → NP_001382018.1  bromodomain-containing protein 9 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    Conserved Domains (2) summary
    pfam12024
    Location:79 → 258
    DUF3512; Domain of unknown function (DUF3512)
    cl02556
    Location:1 → 30
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  5. NM_001395090.1 → NP_001382019.1  bromodomain-containing protein 9 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    Conserved Domains (1) summary
    cl02556
    Location:1 → 30
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    31158546..31185812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006227787.4 → XP_006227849.1  bromodomain-containing protein 9 isoform X1

    UniProtKB/TrEMBL
    A6JUV9
    Conserved Domains (2) summary
    cd05513
    Location:246 → 343
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
    pfam12024
    Location:379 → 608
    DUF3512; Domain of unknown function (DUF3512)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107453.1: Suppressed sequence

    Description
    NM_001107453.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
Nucleotide Protein Strain
Heading Accession and Version

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