U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zfp541 zinc finger protein 541 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308108, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Zfp541provided by RGD
Official Full Name
zinc finger protein 541provided by RGD
Primary source
RGD:1310756
See related
EnsemblRapid:ENSRNOG00000021800 AllianceGenome:RGD:1310756
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Znf541
Summary
Predicted to enable transcription corepressor activity. Predicted to be involved in male meiotic nuclear division and regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex and transcription regulator complex. Orthologous to human ZNF541 (zinc finger protein 541). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Testes (RPKM 63.4) and Liver (RPKM 1.8) See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Zfp541 in Genome Data Viewer
Location:
1q21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (85878329..85914754)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (76750236..76786567)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (77957188..77993816)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene EH-domain containing 2 Neighboring gene uncharacterized LOC103691043 Neighboring gene BRD4 interacting chromatin remodeling complex associated protein Neighboring gene NSF attachment protein alpha Neighboring gene kaptin (actin binding protein)

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A novel germ cell-specific protein, SHIP1, forms a complex with chromatin remodeling activity during spermatogenesis. Choi E, et al. J Biol Chem, 2008 Dec 12. PMID 18849567, Free PMC Article
  2. Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library. Choi E, et al. BMC Genomics, 2007 Jul 28. PMID 17662146, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in male meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of histone deacetylase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 541

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107458.2 → NP_001100928.2  zinc finger protein 541

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    D3Z8I0
    Conserved Domains (6) summary
    PHA03247
    Location:244 → 672
    PHA03247; large tegument protein UL36; Provisional
    COG5236
    Location:80 → 227
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:142 → 162
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:168 → 190
    zf-C2H2; Zinc finger, C2H2 type
    pfam01448
    Location:1003 → 1058
    ELM2; ELM2 domain
    cl21498
    Location:1113 → 1156
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    85878329..85914754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288451.1 → XP_063144521.1  zinc finger protein 541 isoform X1

    UniProtKB/TrEMBL
    D3Z8I0

  2. XM_063288450.1 → XP_063144520.1  zinc finger protein 541 isoform X1

    UniProtKB/TrEMBL
    D3Z8I0
    Related
    ENSRNOP00000055040.2, ENSRNOT00000058241.6

  3. XM_003748775.6 → XP_003748823.1  zinc finger protein 541 isoform X1

    See identical proteins and their annotated locations for XP_003748823.1

    UniProtKB/TrEMBL
    D3Z8I0
    Conserved Domains (6) summary
    PHA03247
    Location:244 → 672
    PHA03247; large tegument protein UL36; Provisional
    COG5236
    Location:80 → 227
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:142 → 162
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:168 → 190
    zf-C2H2; Zinc finger, C2H2 type
    pfam01448
    Location:1003 → 1058
    ELM2; ELM2 domain
    cl21498
    Location:1113 → 1156
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  4. XM_006228357.5 → XP_006228419.1  zinc finger protein 541 isoform X1

    See identical proteins and their annotated locations for XP_006228419.1

    UniProtKB/TrEMBL
    D3Z8I0
    Conserved Domains (6) summary
    PHA03247
    Location:244 → 672
    PHA03247; large tegument protein UL36; Provisional
    COG5236
    Location:80 → 227
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:142 → 162
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:168 → 190
    zf-C2H2; Zinc finger, C2H2 type
    pfam01448
    Location:1003 → 1058
    ELM2; ELM2 domain
    cl21498
    Location:1113 → 1156
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  5. XM_063288456.1 → XP_063144526.1  zinc finger protein 541 isoform X1

    UniProtKB/TrEMBL
    D3Z8I0

  6. XM_039110599.2 → XP_038966527.1  zinc finger protein 541 isoform X1

    UniProtKB/TrEMBL
    D3Z8I0
    Conserved Domains (6) summary
    PHA03247
    Location:244 → 672
    PHA03247; large tegument protein UL36; Provisional
    COG5236
    Location:80 → 227
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:142 → 162
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:168 → 190
    zf-C2H2; Zinc finger, C2H2 type
    pfam01448
    Location:1003 → 1058
    ELM2; ELM2 domain
    cl21498
    Location:1113 → 1156
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools