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Zfp574 zinc finger protein 574 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308434, updated on 27-Nov-2024

Summary

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Official Symbol
Zfp574provided by RGD
Official Full Name
zinc finger protein 574provided by RGD
Primary source
RGD:1311420
See related
EnsemblRapid:ENSRNOG00000055761 AllianceGenome:RGD:1311420
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Znf574
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF574 (zinc finger protein 574). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 53.3), Kidney (RPKM 46.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp574 in Genome Data Viewer
Location:
1q21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (89798412..89805490)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (80667984..80678257)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (81952067..81957330)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ATPase Na+/K+ transporting subunit alpha 3 Neighboring gene glutamate ionotropic receptor kainate type subunit 5 Neighboring gene POU class 2 homeobox 2 Neighboring gene uncharacterized LOC103691054 Neighboring gene U6 spliceosomal RNA Neighboring gene death effector domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 574

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024258.1 → NP_001019429.1  zinc finger protein 574

    See identical proteins and their annotated locations for NP_001019429.1

    Status: PROVISIONAL

    Source sequence(s)
    BC094953
    UniProtKB/Swiss-Prot
    Q504L7
    UniProtKB/TrEMBL
    A6J938
    Related
    ENSRNOP00000082869.1, ENSRNOT00000116503.2
    Conserved Domains (4) summary
    cd11674
    Location:458 → 492
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:496 → 850
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:498 → 518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:312 → 391
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    89798412..89805490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111384.2 → XP_038967312.1  zinc finger protein 574 isoform X2

    UniProtKB/Swiss-Prot
    Q504L7
    UniProtKB/TrEMBL
    A6J938
    Related
    ENSRNOP00000083524.1, ENSRNOT00000096464.2
    Conserved Domains (4) summary
    cd11674
    Location:458 → 492
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:496 → 850
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:498 → 518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:312 → 391
    zf-C2H2_8; C2H2-type zinc ribbon

  2. XM_008758930.3 → XP_008757152.1  zinc finger protein 574 isoform X2

    See identical proteins and their annotated locations for XP_008757152.1

    UniProtKB/Swiss-Prot
    Q504L7
    UniProtKB/TrEMBL
    A6J938
    Related
    ENSRNOP00000089598.1, ENSRNOT00000110459.2
    Conserved Domains (4) summary
    cd11674
    Location:458 → 492
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:496 → 850
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:498 → 518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:312 → 391
    zf-C2H2_8; C2H2-type zinc ribbon

  3. XM_008758931.4 → XP_008757153.1  zinc finger protein 574 isoform X2

    See identical proteins and their annotated locations for XP_008757153.1

    UniProtKB/Swiss-Prot
    Q504L7
    UniProtKB/TrEMBL
    A6J938
    Conserved Domains (4) summary
    cd11674
    Location:458 → 492
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:496 → 850
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:498 → 518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:312 → 391
    zf-C2H2_8; C2H2-type zinc ribbon

  4. XM_039111397.2 → XP_038967325.1  zinc finger protein 574 isoform X2

    UniProtKB/Swiss-Prot
    Q504L7
    UniProtKB/TrEMBL
    A6J938
    Conserved Domains (4) summary
    cd11674
    Location:458 → 492
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:496 → 850
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:498 → 518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:312 → 391
    zf-C2H2_8; C2H2-type zinc ribbon

  5. XM_039111377.2 → XP_038967305.1  zinc finger protein 574 isoform X1

    Related
    ENSRNOP00000070796.2, ENSRNOT00000079847.3
    Conserved Domains (4) summary
    cd11674
    Location:469 → 503
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:507 → 861
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:509 → 529
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:323 → 402
    zf-C2H2_8; C2H2-type zinc ribbon
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q504L7.1 GenPept UniProtKB/Swiss-Prot:Q504L7

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