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Spred3 sprouty-related, EVH1 domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308478, updated on 27-Nov-2024

Summary

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Official Symbol
Spred3provided by RGD
Official Full Name
sprouty-related, EVH1 domain containing 3provided by RGD
Primary source
RGD:1311713
See related
EnsemblRapid:ENSRNOG00000051915 AllianceGenome:RGD:1311713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311713
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in negative regulation of cell differentiation and negative regulation of signal transduction. Predicted to act upstream of or within negative regulation of MAPK cascade. Predicted to be active in plasma membrane. Orthologous to human SPRED3 (sprouty related EVH1 domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 37.9), Brain (RPKM 23.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Spred3 in Genome Data Viewer
Location:
1q21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93586259..93597692, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84458779..84470425, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (88101213..88112719, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene ryanodine receptor 1 Neighboring gene RAS guanyl releasing protein 4 Neighboring gene family with sequence similarity 98, member C Neighboring gene proteasome 26S subunit, non-ATPase 8 Neighboring gene gametogenetin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. Kato R, et al. Biochem Biophys Res Commun, 2003 Mar 21. PMID 12646235
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables stem cell factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of lens fiber cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sprouty-related, EVH1 domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415863.1 → NP_001402792.1  sprouty-related, EVH1 domain-containing protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A096MJ78, A6J9N6
    Related
    ENSRNOP00000086038.2, ENSRNOT00000113063.2

RNA

  1. NR_183230.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    93586259..93597692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759145.4 → XP_008757367.2  sprouty-related, EVH1 domain-containing protein 3 isoform X1

    Related
    ENSRNOP00000105772.1, ENSRNOT00000144520.1

  2. XM_017589125.3 → XP_017444614.1  sprouty-related, EVH1 domain-containing protein 3 isoform X2

    Related
    ENSRNOP00000072614.2, ENSRNOT00000090615.3

  3. XM_039111582.2 → XP_038967510.1  sprouty-related, EVH1 domain-containing protein 3 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K3F4, B2GV40
    Conserved Domains (3) summary
    PRK12323
    Location:126 → 229
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam05210
    Location:265 → 369
    Sprouty; Sprouty protein (Spry)
    cl17171
    Location:2 → 84
    PH-like; Pleckstrin homology-like domain

  4. XM_008759146.3 → XP_008757368.1  sprouty-related, EVH1 domain-containing protein 3 isoform X3

    See identical proteins and their annotated locations for XP_008757368.1

    UniProtKB/TrEMBL
    A0A096MJ78, A0A0G2K3F4, A6J9N6, B2GV40
    Conserved Domains (2) summary
    cd10574
    Location:2 → 115
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    pfam05210
    Location:296 → 393
    Sprouty; Sprouty protein (Spry)

  5. XM_039111583.2 → XP_038967511.1  sprouty-related, EVH1 domain-containing protein 3 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K3F4, B2GV40
    Related
    ENSRNOP00000098719.1, ENSRNOT00000138145.1
    Conserved Domains (3) summary
    PRK12323
    Location:126 → 229
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam05210
    Location:265 → 369
    Sprouty; Sprouty protein (Spry)
    cl17171
    Location:2 → 84
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version

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