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Fuz fuzzy planar cell polarity protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 308577, updated on 9-Dec-2024

Summary

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Official Symbol
Fuzprovided by RGD
Official Full Name
fuzzy planar cell polarity proteinprovided by RGD
Primary source
RGD:1310608
See related
EnsemblRapid:ENSRNOG00000053084 AllianceGenome:RGD:1310608
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310608
Summary
Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including embryonic morphogenesis; non-motile cilium assembly; and regulation of signal transduction. Predicted to act upstream of or within several processes, including circulatory system development; embryonic morphogenesis; and regionalization. Predicted to be located in cell projection; cytoplasm; and cytoskeleton. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human FUZ (fuzzy planar cell polarity protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Muscle (RPKM 59.8), Brain (RPKM 49.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fuz in Genome Data Viewer
Location:
1q22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104515782..104524591)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95379542..95384532)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100891832..100896811)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene PTOV1, extended AT-hook containing adaptor protein Neighboring gene mediator complex subunit 25 Neighboring gene adaptor related protein complex 2 subunit alpha 1 Neighboring gene transfer RNA proline (anticodon AGG) 45 Neighboring gene testis-specific serine kinase substrate Neighboring gene carnitine palmitoyltransferase 1c

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in the planar cell polarity gene, Fuzzy, are associated with neural tube defects in humans. Seo JH, et al. Hum Mol Genet, 2011 Nov 15. PMID 21840926
  2. The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development. Gray RS, et al. Nat Cell Biol, 2009 Oct. PMID 19767740, Free PMC Article
  3. A novel ciliopathic skull defect arising from excess neural crest. Tabler JM, et al. Dev Biol, 2016 Sep 1. PMID 27395007, Free PMC Article
  4. The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery. Toriyama M, et al. Nat Genet, 2016 Jun. PMID 27158779, Free PMC Article
  5. Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx. Tabler JM, et al. Elife, 2017 Feb 13. PMID 28177282, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC125220

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within aorta development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cardiac septum development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within coronary vasculature development ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic body morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic body morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic neurocranium morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic skeletal system morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in establishment of planar polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of planar polarity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hair follicle development ISO
Inferred from Sequence Orthology
more info
  
involved_in hair follicle development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within larynx morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of neural crest formation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neural crest formation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within neural tube closure ISO
Inferred from Sequence Orthology
more info
  
involved_in neural tube closure ISO
Inferred from Sequence Orthology
more info
  
involved_in neural tube closure ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in non-motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in non-motile cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within roof of mouth development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spinal cord development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spinal cord dorsal/ventral patterning ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tongue morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein fuzzy homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037646.2 → NP_001032735.1  protein fuzzy homolog isoform 2

    See identical proteins and their annotated locations for NP_001032735.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5XV94
    Related
    ENSRNOP00000074982.1, ENSRNOT00000086890.3

  2. NM_001399381.1 → NP_001386310.1  protein fuzzy homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q3B756
    UniProtKB/TrEMBL
    A0A8I5XV94, A6JAU2
    Related
    ENSRNOP00000070688.1, ENSRNOT00000083336.3
    Conserved Domains (1) summary
    cd21091
    Location:12 → 413
    Fuzzy; protein fuzzy and homologs

  3. NM_001399382.1 → NP_001386311.1  protein fuzzy homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    Conserved Domains (1) summary
    cl40581
    Location:12 → 322
    Fuzzy; protein fuzzy and homologs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    104515782..104524591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229060.5 → XP_006229122.1  protein fuzzy homolog isoform X2

    UniProtKB/TrEMBL
    A0A8I5XV94, A0A8I6ABP8
    Related
    ENSRNOP00000091471.1, ENSRNOT00000114637.2

  2. XM_039112059.2 → XP_038967987.1  protein fuzzy homolog isoform X7

    Conserved Domains (1) summary
    cl40581
    Location:12 → 263
    Fuzzy; protein fuzzy and homologs

  3. XM_063261942.1 → XP_063118012.1  protein fuzzy homolog isoform X4

  4. XM_063261966.1 → XP_063118036.1  protein fuzzy homolog isoform X9

  5. XM_063261949.1 → XP_063118019.1  protein fuzzy homolog isoform X7

  6. XM_039112029.2 → XP_038967957.1  protein fuzzy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I5XV94
    Related
    ENSRNOP00000112429.1, ENSRNOT00000152626.1
    Conserved Domains (1) summary
    cl40581
    Location:12 → 390
    Fuzzy; protein fuzzy and homologs

  7. XM_039112048.2 → XP_038967976.1  protein fuzzy homolog isoform X6

    UniProtKB/TrEMBL
    A0A8I5XV94
    Conserved Domains (1) summary
    cl40581
    Location:12 → 324
    Fuzzy; protein fuzzy and homologs

  8. XM_063261955.1 → XP_063118025.1  protein fuzzy homolog isoform X8

  9. XM_006229061.5 → XP_006229123.1  protein fuzzy homolog isoform X3

    UniProtKB/TrEMBL
    A0A8I5XV94

  10. XM_039112046.2 → XP_038967974.1  protein fuzzy homolog isoform X5

    UniProtKB/TrEMBL
    A0A8I5XV94
    Conserved Domains (1) summary
    cl40581
    Location:20 → 332
    Fuzzy; protein fuzzy and homologs

  11. XM_039112064.2 → XP_038967992.1  protein fuzzy homolog isoform X10

    Conserved Domains (1) summary
    cl40581
    Location:1 → 251
    Fuzzy; protein fuzzy and homologs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3B756.2 GenPept UniProtKB/Swiss-Prot:Q3B756

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