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Ap2a1 adaptor related protein complex 2 subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308578, updated on 3-Dec-2024

Summary

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Official Symbol
Ap2a1provided by RGD
Official Full Name
adaptor related protein complex 2 subunit alpha 1provided by RGD
Primary source
RGD:1306254
See related
EnsemblRapid:ENSRNOG00000026243 AllianceGenome:RGD:1306254
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable clathrin adaptor activity; low-density lipoprotein particle receptor binding activity; and protein kinase binding activity. Involved in positive regulation of neuron projection development and positive regulation of receptor-mediated endocytosis. Located in apical plasma membrane; basolateral plasma membrane; and clathrin-coated vesicle. Part of protein-containing complex. Is active in synaptic vesicle. Orthologous to human AP2A1 (adaptor related protein complex 2 subunit alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 124.7), Kidney (RPKM 81.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ap2a1 in Genome Data Viewer
Location:
1q22
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104520789..104550655, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95384306..95414170, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100896582..100926443, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene PTOV1, extended AT-hook containing adaptor protein Neighboring gene mediator complex subunit 25 Neighboring gene fuzzy planar cell polarity protein Neighboring gene transfer RNA proline (anticodon AGG) 45 Neighboring gene testis-specific serine kinase substrate Neighboring gene carnitine palmitoyltransferase 1c

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The role of endocytic l1 trafficking in polarized adhesion and migration of nerve growth cones. Kamiguchi H, et al. J Neurosci, 2001 Dec 1. PMID 11717353, Free PMC Article
  2. Evidence on differential role for alpha 1 and alpha 2 subtypes of AP-2 adaptin in the central nervous system. Capella P, et al. Neurosci Lett, 2023 Jun 21. PMID 37127089
  3. Co-localization of rab4 with endocytosis-related proteins in the rat parotid glands. Nashida T, et al. Arch Histol Cytol, 2003 Mar. PMID 12703553
  4. The interaction of epsin and Eps15 with the clathrin adaptor AP-2 is inhibited by mitotic phosphorylation and enhanced by stimulation-dependent dephosphorylation in nerve terminals. Chen H, et al. J Biol Chem, 1999 Feb 5. PMID 9920862
  5. Inhibition of receptor-mediated endocytosis by the amphiphysin SH3 domain. Wigge P, et al. Curr Biol, 1997 Aug 1. PMID 9259551

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Evidence on differential role for alpha 1 and alpha 2 subtypes of AP-2 adaptin in the central nervous system.
    Title: Evidence on differential role for alpha 1 and alpha 2 subtypes of AP-2 adaptin in the central nervous system.
  2. SP-A transiently enhances the basal protein expression of CHC and alpha-adaptin.
    Title: Surfactant Protein A Enhances Constitutive Immune Functions of Clathrin Heavy Chain and Clathrin Adaptor Protein 2.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of hyaluronan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of AP-2 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AP-2 adaptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in filopodium tip ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
part_of membrane coat ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic endocytic zone ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
AP-2 complex subunit alpha-1
Names
adaptor protein complex AP-2, alpha 1 subunit
adaptor-related protein complex 2, alpha 1 subunit
alpha-adaptin A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395092.1 → NP_001382021.1  AP-2 complex subunit alpha-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6JAU3
    Related
    ENSRNOP00000020304.7, ENSRNOT00000020304.8
    Conserved Domains (3) summary
    smart00809
    Location:755 → 858
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam02296
    Location:864 → 972
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region

  2. NM_001395093.1 → NP_001382022.1  AP-2 complex subunit alpha-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    D3ZUY8
    Conserved Domains (4) summary
    smart00809
    Location:733 → 836
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332 → 355
    HEAT; HEAT repeat [structural motif]
    pfam02296
    Location:842 → 950
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    104520789..104550655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261978.1 → XP_063118048.1  AP-2 complex subunit alpha-1 isoform X3

    UniProtKB/TrEMBL
    D3ZUY8
    Related
    ENSRNOP00000087357.1, ENSRNOT00000097722.2

  2. XM_063261976.1 → XP_063118046.1  AP-2 complex subunit alpha-1 isoform X2

    UniProtKB/TrEMBL
    A6JAU3
    Related
    ENSRNOP00000086051.1, ENSRNOT00000101662.2

  3. XM_063261974.1 → XP_063118044.1  AP-2 complex subunit alpha-1 isoform X1

    UniProtKB/TrEMBL
    D3ZUY8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107511.2: Suppressed sequence

    Description
    NM_001107511.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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