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Plekha4 pleckstrin homology domain containing A4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308584, updated on 27-Nov-2024

Summary

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Official Symbol
Plekha4provided by RGD
Official Full Name
pleckstrin homology domain containing A4provided by RGD
Primary source
RGD:735133
See related
EnsemblRapid:ENSRNOG00000020942 AllianceGenome:RGD:735133
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity; phosphatidylinositol phosphate binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in positive regulation of Wnt signaling pathway, planar cell polarity pathway and positive regulation of canonical Wnt signaling pathway. Predicted to be located in cytoplasm. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human PLEKHA4 (pleckstrin homology domain containing A4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 44.4), Muscle (RPKM 41.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plekha4 in Genome Data Viewer
Location:
1q22
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105142296..105165297)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96005824..96028826)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101517702..101540802)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene TUB like protein 2 Neighboring gene nucleobindin 1 Neighboring gene protein phosphatase 1, regulatory subunit 15A Neighboring gene transfer RNA serine (anticodon AGA) 17 Neighboring gene uncharacterized LOC120097182 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 14 Neighboring gene uncharacterized LOC102556190 Neighboring gene branched chain amino acid transaminase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Dowler S, et al. Biochem J, 2000 Oct 1. PMID 11001876, Free PMC Article
  2. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. Shami Shah A, et al. Cell Rep, 2019 May 14. PMID 31091453, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC72599

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family A member 4
Names
PEPP-1
PH domain-containing family A member 4
phosphoinositol 3-phosphate-binding protein 1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199101.1 → NP_954532.1  pleckstrin homology domain-containing family A member 4

    See identical proteins and their annotated locations for NP_954532.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061738
    UniProtKB/Swiss-Prot
    P60669
    UniProtKB/TrEMBL
    A0A8I5ZVU5
    Related
    ENSRNOP00000028423.4, ENSRNOT00000028423.7
    Conserved Domains (2) summary
    cd13248
    Location:49 → 152
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:55 → 153
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    105142296..105165297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229071.4 → XP_006229133.1  pleckstrin homology domain-containing family A member 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZVU5
    Related
    ENSRNOP00000100346.1, ENSRNOT00000173288.1
    Conserved Domains (2) summary
    cd13248
    Location:49 → 152
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:55 → 153
    PH; PH domain

  2. XM_063262045.1 → XP_063118115.1  pleckstrin homology domain-containing family A member 4 isoform X5

  3. XM_063262037.1 → XP_063118107.1  pleckstrin homology domain-containing family A member 4 isoform X4

  4. XM_039112161.2 → XP_038968089.1  pleckstrin homology domain-containing family A member 4 isoform X4

    UniProtKB/TrEMBL
    A0A8I6GKA6
    Conserved Domains (2) summary
    COG1196
    Location:232 → 344
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl17171
    Location:1 → 25
    PH-like; Pleckstrin homology-like domain

  5. XM_039112147.2 → XP_038968075.1  pleckstrin homology domain-containing family A member 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZVU5, A6JB50
    Related
    ENSRNOP00000093447.2, ENSRNOT00000097781.2
    Conserved Domains (2) summary
    COG1196
    Location:331 → 443
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:49 → 152
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

  6. XM_006229072.4 → XP_006229134.1  pleckstrin homology domain-containing family A member 4 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZVU5
    Conserved Domains (2) summary
    cd13248
    Location:49 → 152
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:55 → 153
    PH; PH domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60669.1 GenPept UniProtKB/Swiss-Prot:P60669

Gene LinkOut

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