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Sec1 secretory blood group 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308586, updated on 27-Nov-2024

Summary

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Official Symbol
Sec1provided by RGD
Official Full Name
secretory blood group 1provided by RGD
Primary source
RGD:1562499
See related
EnsemblRapid:ENSRNOG00000021014 AllianceGenome:RGD:1562499
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ftc; RGD1562499
Summary
Predicted to enable galactoside 2-alpha-L-fucosyltransferase activity. Predicted to be involved in fucosylation and protein glycosylation. Predicted to be located in Golgi cisterna membrane. Human ortholog(s) of this gene implicated in vitamin B12 deficiency. Orthologous to human FUT2 (fucosyltransferase 2 (H blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 23.8), Adrenal (RPKM 5.1) and 3 other tissues See more
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Genomic context

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See Sec1 in Genome Data Viewer
Location:
1q22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105287093..105301588, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96143390..96164249, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101663205..101677016, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MEF2 activating motif and SAP domain containing transcriptional regulator Neighboring gene fucosyltransferase 2 Neighboring gene netrin 5 Neighboring gene carbonic anhydrase 11 Neighboring gene D-box binding PAR bZIP transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. An amino acid region at the N-terminus of rat hepatoma alpha1-->2 fucosyltransferase modulates enzyme activity and interaction with lipids: strong preference for glycosphingolipids containing terminal Galbeta1-->3GalNAc-structures. Sherwood AL, et al. Biochemistry, 2001 May 15. PMID 11341836
  2. Cloning and expression of the catalytic domain from rat hepatoma H35 cell GDP-fucose:GM1 alpha 1-->2fucosyltransferase, an enzyme which is activated during early stages of chemical carcinogenesis in rat liver. Sherwood AL, et al. Arch Biochem Biophys, 1998 Jul 15. PMID 9675030
  3. Evidence for two distinct alpha(1,2)-fucosyltransferase genes differentially expressed throughout the rat colon. Piau JP, et al. Biochem J, 1994 Jun 15. PMID 8010942, Free PMC Article
  4. Comparison of the three rat GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferases FTA, FTB and FTC. Bureau V, et al. Eur J Biochem, 2001 Feb. PMID 11179967
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables galactoside 2-alpha-L-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fucosyltransferase 10
Names
alpha 1,2-fucosyltransferase C
NP_001129056.1
XP_008757601.1
XP_017444629.1
XP_017444630.1
XP_038968114.1
XP_038968126.1
XP_038968134.1
XP_038968138.1
XP_038968143.1
XP_038968147.1
XP_038968163.1
XP_038968173.1
XP_063118128.1
XP_063118150.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135584.1 → NP_001129056.1  fucosyltransferase 10

    See identical proteins and their annotated locations for NP_001129056.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6JB67, Q9WUE6
    Conserved Domains (1) summary
    pfam01531
    Location:1 → 272
    Glyco_transf_11; Glycosyl transferase family 11

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    105287093..105301588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017589141.3 → XP_017444630.1  fucosyltransferase 10 isoform X1

    UniProtKB/TrEMBL
    F1MAG9
    Conserved Domains (1) summary
    pfam01531
    Location:55 → 362
    Glyco_transf_11; Glycosyl transferase family 11

  2. XM_017589140.3 → XP_017444629.1  fucosyltransferase 10 isoform X1

    UniProtKB/TrEMBL
    F1MAG9
    Related
    ENSRNOP00000028522.6, ENSRNOT00000028522.9
    Conserved Domains (1) summary
    pfam01531
    Location:55 → 362
    Glyco_transf_11; Glycosyl transferase family 11

  3. XM_039112235.2 → XP_038968163.1  fucosyltransferase 10 isoform X2

    UniProtKB/TrEMBL
    A6JB67, Q9WUE6
    Conserved Domains (1) summary
    pfam01531
    Location:1 → 272
    Glyco_transf_11; Glycosyl transferase family 11

  4. XM_039112210.2 → XP_038968138.1  fucosyltransferase 10 isoform X2

    UniProtKB/TrEMBL
    A6JB67, Q9WUE6
    Conserved Domains (1) summary
    pfam01531
    Location:1 → 272
    Glyco_transf_11; Glycosyl transferase family 11

  5. XM_039112186.2 → XP_038968114.1  fucosyltransferase 10 isoform X1

    UniProtKB/TrEMBL
    F1MAG9
    Conserved Domains (1) summary
    pfam01531
    Location:55 → 362
    Glyco_transf_11; Glycosyl transferase family 11

  6. XM_008759379.4 → XP_008757601.1  fucosyltransferase 10 isoform X2

    See identical proteins and their annotated locations for XP_008757601.1

    UniProtKB/TrEMBL
    A6JB67, Q9WUE6
    Conserved Domains (1) summary
    pfam01531
    Location:1 → 272
    Glyco_transf_11; Glycosyl transferase family 11

  7. XM_039112245.2 → XP_038968173.1  fucosyltransferase 10 isoform X2

    UniProtKB/TrEMBL
    A6JB67, Q9WUE6
    Conserved Domains (1) summary
    pfam01531
    Location:1 → 272
    Glyco_transf_11; Glycosyl transferase family 11

  8. XM_039112219.2 → XP_038968147.1  fucosyltransferase 10 isoform X2

    UniProtKB/TrEMBL
    A6JB67, Q9WUE6
    Conserved Domains (1) summary
    pfam01531
    Location:1 → 272
    Glyco_transf_11; Glycosyl transferase family 11

  9. XM_039112206.2 → XP_038968134.1  fucosyltransferase 10 isoform X2

    UniProtKB/TrEMBL
    A6JB67, Q9WUE6
    Conserved Domains (1) summary
    pfam01531
    Location:1 → 272
    Glyco_transf_11; Glycosyl transferase family 11

  10. XM_063262080.1 → XP_063118150.1  fucosyltransferase 10 isoform X2

    UniProtKB/TrEMBL
    A6JB67

  11. XM_039112215.2 → XP_038968143.1  fucosyltransferase 10 isoform X2

    UniProtKB/TrEMBL
    A6JB67, Q9WUE6
    Conserved Domains (1) summary
    pfam01531
    Location:1 → 272
    Glyco_transf_11; Glycosyl transferase family 11

  12. XM_063262058.1 → XP_063118128.1  fucosyltransferase 10 isoform X1

    UniProtKB/TrEMBL
    F1MAG9

  13. XM_039112198.2 → XP_038968126.1  fucosyltransferase 10 isoform X1

    UniProtKB/TrEMBL
    F1MAG9
    Conserved Domains (1) summary
    pfam01531
    Location:55 → 362
    Glyco_transf_11; Glycosyl transferase family 11
Nucleotide Protein Strain
Heading Accession and Version

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