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Unc45a unc-45 myosin chaperone A [ Rattus norvegicus (Norway rat) ]

Gene ID: 308759, updated on 27-Nov-2024

Summary

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Official Symbol
Unc45aprovided by RGD
Official Full Name
unc-45 myosin chaperone Aprovided by RGD
Primary source
RGD:1305357
See related
EnsemblRapid:ENSRNOG00000012357 AllianceGenome:RGD:1305357
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305357
Summary
Predicted to enable Hsp90 protein binding activity. Predicted to be involved in chaperone-mediated protein folding. Predicted to be located in Golgi apparatus; cytosol; and nuclear speck. Predicted to be active in cytoplasm. Orthologous to human UNC45A (unc-45 myosin chaperone A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 81.5), Kidney (RPKM 63.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Unc45a in Genome Data Viewer
Location:
1q31
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143691183..143705944, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (134281930..134296661, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142118910..142135219, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene protein regulator of cytokinesis 1 Neighboring gene RCC1 domain containing 1 Neighboring gene shisa like 3 Neighboring gene HD domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Unc45 activates Hsp90-dependent folding of the myosin motor domain. Liu L, et al. J Biol Chem, 2008 May 9. PMID 18326487, Free PMC Article
  2. Association of connexin43 with E3 ubiquitin ligase TRIM21 reveals a mechanism for gap junction phosphodegron control. Chen VC, et al. J Proteome Res, 2012 Dec 7. PMID 23106098
  3. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC125248

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Hsp90 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in chaperone-mediated protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
  
involved_in muscle organ development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein unc-45 homolog A
Names
SMAP-1
UNC-45A
smooth muscle cell-associated protein 1
unc-45 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037647.1 → NP_001032736.1  protein unc-45 homolog A

    See identical proteins and their annotated locations for NP_001032736.1

    Status: PROVISIONAL

    Source sequence(s)
    BC107919
    UniProtKB/Swiss-Prot
    Q32PZ3
    UniProtKB/TrEMBL
    A0A8I5ZTS5, A6JCA2
    Related
    ENSRNOP00000082238.1, ENSRNOT00000110547.2
    Conserved Domains (6) summary
    cd00020
    Location:684 → 803
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00006
    Location:21 → 49
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:92 → 125
    TPR_1; Tetratricopeptide repeat
    pfam11701
    Location:361 → 505
    UNC45-central; Myosin-binding striated muscle assembly central
    pfam13414
    Location:20 → 88
    TPR_11; TPR repeat
    sd00043
    Location:768 → 803
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    143691183..143705944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229432.5 → XP_006229494.1  protein unc-45 homolog A isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZTS5
    Related
    ENSRNOP00000017407.5, ENSRNOT00000017407.8
    Conserved Domains (6) summary
    cd00020
    Location:669 → 788
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00006
    Location:6 → 34
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:77 → 110
    TPR_1; Tetratricopeptide repeat
    pfam11701
    Location:346 → 490
    UNC45-central; Myosin-binding striated muscle assembly central
    pfam13414
    Location:5 → 73
    TPR_11; TPR repeat
    sd00043
    Location:753 → 788
    ARM; armadillo repeat [structural motif]

  2. XM_039112980.2 → XP_038968908.1  protein unc-45 homolog A isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZTS5
    Conserved Domains (1) summary
    pfam11701
    Location:216 → 360
    UNC45-central; Myosin-binding striated muscle assembly central
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32PZ3.1 GenPept UniProtKB/Swiss-Prot:Q32PZ3

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