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Prc1 protein regulator of cytokinesis 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308761, updated on 27-Nov-2024

Summary

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Official Symbol
Prc1provided by RGD
Official Full Name
protein regulator of cytokinesis 1provided by RGD
Primary source
RGD:1311754
See related
EnsemblRapid:ENSRNOG00000013057 AllianceGenome:RGD:1311754
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cytoskeletal protein binding activity; identical protein binding activity; and protein kinase binding activity. Predicted to be involved in mitotic spindle midzone assembly; positive regulation of cell population proliferation; and regulation of cytokinesis. Predicted to be located in several cellular components, including contractile ring; intercellular bridge; and midbody. Predicted to be active in cytoplasm and mitotic spindle midzone. Orthologous to human PRC1 (protein regulator of cytokinesis 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 231.5), Thymus (RPKM 231.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prc1 in Genome Data Viewer
Location:
1q31
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143659312..143681019)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (134250086..134271765)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142087181..142108746)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene neugrin, neurite outgrowth associated Neighboring gene VPS33B, late endosome and lysosome associated Neighboring gene small nucleolar RNA SNORA48 Neighboring gene RCC1 domain containing 1 Neighboring gene unc-45 myosin chaperone A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein. Subramanian R, et al. Cell, 2010 Aug 6. PMID 20691902, Free PMC Article
  2. Spatiotemporal control of spindle midzone formation by PRC1 in human cells. Zhu C, et al. Proc Natl Acad Sci U S A, 2006 Apr 18. PMID 16603632, Free PMC Article
  3. Marking and measuring single microtubules by PRC1 and kinesin-4. Subramanian R, et al. Cell, 2013 Jul 18. PMID 23870126, Free PMC Article
  4. Oncogenic role of MPHOSPH1, a cancer-testis antigen specific to human bladder cancer. Kanehira M, et al. Cancer Res, 2007 Apr 1. PMID 17409436
  5. Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1. Neef R, et al. Nat Cell Biol, 2007 Apr. PMID 17351640

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in contractile ring ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein regulator of cytokinesis 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107529.1 → NP_001100999.1  protein regulator of cytokinesis 1

    See identical proteins and their annotated locations for NP_001100999.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473980
    UniProtKB/TrEMBL
    A6JC95, A6JC96, D3ZES9
    Related
    ENSRNOP00000017532.4, ENSRNOT00000017532.7
    Conserved Domains (1) summary
    pfam03999
    Location:37 → 601
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    143659312..143681019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229437.5 → XP_006229499.1  protein regulator of cytokinesis 1 isoform X6

    See identical proteins and their annotated locations for XP_006229499.1

    UniProtKB/TrEMBL
    A0A8I6A8F8, A0A8I6APR6, A6JC97
    Related
    ENSRNOP00000095742.1, ENSRNOT00000095280.2
    Conserved Domains (1) summary
    pfam03999
    Location:37 → 562
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  2. XM_006229433.5 → XP_006229495.1  protein regulator of cytokinesis 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6APJ5, A6JC95
    Related
    ENSRNOP00000095649.1, ENSRNOT00000110073.2
    Conserved Domains (1) summary
    pfam03999
    Location:37 → 615
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  3. XM_006229435.5 → XP_006229497.1  protein regulator of cytokinesis 1 isoform X4

    UniProtKB/TrEMBL
    A6JC95
    Related
    ENSRNOP00000090144.2, ENSRNOT00000101538.2
    Conserved Domains (2) summary
    pfam03999
    Location:37 → 578
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam13094
    Location:34 → 155
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit

  4. XM_063262643.1 → XP_063118713.1  protein regulator of cytokinesis 1 isoform X5

  5. XM_039113027.2 → XP_038968955.1  protein regulator of cytokinesis 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I6APR6
    Conserved Domains (1) summary
    pfam03999
    Location:37 → 511
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  6. XM_039113001.2 → XP_038968929.1  protein regulator of cytokinesis 1 isoform X2

    UniProtKB/TrEMBL
    A6JC95
    Conserved Domains (1) summary
    pfam03999
    Location:37 → 612
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  7. XM_039113007.2 → XP_038968935.1  protein regulator of cytokinesis 1 isoform X3

    UniProtKB/TrEMBL
    A6JC95
    Conserved Domains (1) summary
    pfam03999
    Location:37 → 598
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  8. XM_063262649.1 → XP_063118719.1  protein regulator of cytokinesis 1 isoform X7

Nucleotide Protein Strain
Heading Accession and Version

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